Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) for PDB: 5MAF
TargetMaternal embryonic leucine zipper kinase(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | Vargatef | US10981896, Co...)
Affinity DataKd:  4.90nMAssay Description:Binding constant for MELK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMaternal embryonic leucine zipper kinase(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | Vargatef | US10981896, Co...)
Affinity DataKi:  5.60nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMaternal embryonic leucine zipper kinase(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | Vargatef | US10981896, Co...)
Affinity DataIC50: 43nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetMaternal embryonic leucine zipper kinase(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | Vargatef | US10981896, Co...)
Affinity DataIC50: 43nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)