Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) for PDB: 5OLO
TargetAdenosine receptor A2a(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50011294(Ro-4494351-002 | Ro-4494351 | SYN-115 | Ro-4494351...)
Affinity DataKi:  0.300nMAssay Description:Antagonist activity at human adenosine A2A receptor expressed in HEK293 cell membranes assessed as decrease in CGS-21680/forskolin-induced cAMP level...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAdenosine receptor A2a(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50011294(Ro-4494351-002 | Ro-4494351 | SYN-115 | Ro-4494351...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity to human adenosine A2A receptor measured by radioligand-based affinity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAdenosine receptor A2a(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50011294(Ro-4494351-002 | Ro-4494351 | SYN-115 | Ro-4494351...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]-ZM241385 from recombinant human A2A receptor expressed in CHO-K1 cells incubated for 70 mins by liquid scintillation counting me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAdenosine receptor A2a(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50011294(Ro-4494351-002 | Ro-4494351 | SYN-115 | Ro-4494351...)
Affinity DataKi:  5nMAssay Description:Antagonist activity at human adenosine 2A receptor (409 to 412 residues) expressed in CHO cells using Ysi-poly-1-lysine as substrate incubated for 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAdenosine receptor A2a(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50011294(Ro-4494351-002 | Ro-4494351 | SYN-115 | Ro-4494351...)
Affinity DataKi:  5nMAssay Description:Antagonist activity at adenosine A2A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAdenosine receptor A2a(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50011294(Ro-4494351-002 | Ro-4494351 | SYN-115 | Ro-4494351...)
Affinity DataKi:  5nMAssay Description:Inhibition of human recombinant adenosine receptor A2aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAdenosine receptor A2a(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50011294(Ro-4494351-002 | Ro-4494351 | SYN-115 | Ro-4494351...)
Affinity DataKi:  8.30nMAssay Description:Displacement of [3H]MSX2 from human adenosine receptor A2A expressed in HEK293 cell membranes incubated for 30 mins by radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAdenosine receptor A2a(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50011294(Ro-4494351-002 | Ro-4494351 | SYN-115 | Ro-4494351...)
Affinity DataKi:  11nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAdenosine receptor A2a(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50011294(Ro-4494351-002 | Ro-4494351 | SYN-115 | Ro-4494351...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cell membranes measured after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)