Report error Found 5 Enz. Inhib. hit(s) for PDB: 6GJ8
TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 230nMAssay Description:Measurement of various protein-protein interactions was performed using the Alpha Screen technology developed by Perkin Elmer. Recombinant RAS protei...More data for this Ligand-Target Pair
3D Structure (crystal)TargetGTPase KRas [G12D]/Son of sevenless homolog 1 [564-1049](Human)
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 310nMAssay Description:The following binding partners have been used in this assay. Biotinylated KRAS G12D protein corresponding to KRAS (amino acids 1-169, with the follow...More data for this Ligand-Target Pair
Affinity DataIC50: 450nMAssay Description:Inhibition of N-terminal 6His-tagged/C-terminal Avi-tagged biotinylated GDP-bound human KRas G12D mutant (1 to 169 residues) assessed as reduction in...More data for this Ligand-Target Pair
Affinity DataKd: 750nMAssay Description:Binding affinity to human GCP-KRAS G12D mutant (1 to 169 residues) expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
Affinity DataKd: 750nMAssay Description:Binding affinity to GTP-KRAS G12D (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair