Report error Found 4 Enz. Inhib. hit(s) for PDB: 6I8M
Affinity DataKd: 10nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKd: 16nMAssay Description:Binding affinity to human recombinant His/GST-tagged PARP1 catalytic domain (655-end residues) by surface plasma resonance methodMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of PARP1 in human HeLa cells assessed as reduction in H2O2-induced PAR formation incubated for 30 mins followed by H2O2 addition for 15 mi...More data for this Ligand-Target Pair
Affinity DataKd: <30nMAssay Description:Displacement of fluorescent probe from human recombinant full length His-tagged PARP1 by fluorescent polarization assayMore data for this Ligand-Target Pair