Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) for PDB: 6IMT
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525174(CHEMBL4592339 | US12145923, Compound (S)-C6)
Affinity DataIC50: 250nMAssay Description:Inhibition of recombinant human PDE4D catalytic domain using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525174(CHEMBL4592339 | US12145923, Compound (S)-C6)
Affinity DataIC50: 5.83E+3nMAssay Description:Inhibition of PDE4 in human PBMC assessed as reduction in LPS-stimulated TNFalpha production preincubated for 1 hr followed by LPS stimulation and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525174(CHEMBL4592339 | US12145923, Compound (S)-C6)
Affinity DataIC50: 2.50E+5nMAssay Description:The scintillation Proximity Assay (SPA) method was used to determine the inhibitory effect of compounds on the activity of PDE4D catalytic domain. Hu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)