Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) for PDB: 6LR4
LigandPNGBDBM28944((2S)-2-hydroxy-3-methyl-N-[(1S)-1-{[(1S)-3-methyl-...)
Affinity DataEC50:  28nMAssay Description:A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28944((2S)-2-hydroxy-3-methyl-N-[(1S)-1-{[(1S)-3-methyl-...)
Affinity DataEC50:  126nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as increase in Abeta38 level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28944((2S)-2-hydroxy-3-methyl-N-[(1S)-1-{[(1S)-3-methyl-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of gamma secretase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28944((2S)-2-hydroxy-3-methyl-N-[(1S)-1-{[(1S)-3-methyl-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of gamma-secretase in human H4 cells assessed as reduction in amyloid beta 42More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28944((2S)-2-hydroxy-3-methyl-N-[(1S)-1-{[(1S)-3-methyl-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of gamma secretase (unknown origin) mediated Notch signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28944((2S)-2-hydroxy-3-methyl-N-[(1S)-1-{[(1S)-3-methyl-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta42 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28944((2S)-2-hydroxy-3-methyl-N-[(1S)-1-{[(1S)-3-methyl-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28944((2S)-2-hydroxy-3-methyl-N-[(1S)-1-{[(1S)-3-methyl-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as decrease in total Abeta level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28944((2S)-2-hydroxy-3-methyl-N-[(1S)-1-{[(1S)-3-methyl-...)
Affinity DataIC50: 126nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as decrease in Abeta42 level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28944((2S)-2-hydroxy-3-methyl-N-[(1S)-1-{[(1S)-3-methyl-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as effect on Abeta40 level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)