Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) for PDB: 6MNE
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandPNGBDBM17289(folliculin | (1S,10R,11S,15S)-5-hydroxy-15-methylt...)
Affinity DataKi:  3nMAssay Description:Inhibition of 17beta-HSD1 assessed as conversion of [14C]estradiol to [14C]estrone using NADP+More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandPNGBDBM17289(folliculin | (1S,10R,11S,15S)-5-hydroxy-15-methylt...)
Affinity DataIC50: 109nMAssay Description:Inhibition of His-tagged human 17beta-HSD1 expressed in Escherichia coli by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandPNGBDBM17289(folliculin | (1S,10R,11S,15S)-5-hydroxy-15-methylt...)
Affinity DataIC50: 218nMAssay Description:Inhibition of 17beta-HSD1 in human T47D cells assessed as inhibition of transformation of [14C]-estrone into [14C]estrogenMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandPNGBDBM17289(folliculin | (1S,10R,11S,15S)-5-hydroxy-15-methylt...)
Affinity DataIC50: 330nMAssay Description:Inhibition of 17-beta HSD1 in T47D cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandPNGBDBM17289(folliculin | (1S,10R,11S,15S)-5-hydroxy-15-methylt...)
Affinity DataIC50: 600nMAssay Description:Inhibition of 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandPNGBDBM17289(folliculin | (1S,10R,11S,15S)-5-hydroxy-15-methylt...)
Affinity DataIC50: 810nMAssay Description:Inhibition of 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol using NADHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandPNGBDBM17289(folliculin | (1S,10R,11S,15S)-5-hydroxy-15-methylt...)
Affinity DataKi:  9.50E+3nMAssay Description:Inhibition of human estradiol 17beta-dehydrogenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)