Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) for PDB: 6P9F
TargetNuclear receptor ROR-gamma(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM253135(US9458171, 95)
Affinity DataEC50:  119nMAssay Description:Inverse agonist activity at GAL4-fused RORgammat LBD (267 to 516 residues) (unknown origin) expressed in human Jurkat cells measured after 18 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma [262-507](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM253135(US9458171, 95)
Affinity DataIC50: 49nMT: 2°CAssay Description:The binding of potential ligands to RORγ is measured by competition with [3H] 25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM253135(US9458171, 95)
Affinity DataIC50: 55nMAssay Description:Binding affinity to RORgammat LBD (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)