Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) for PDB: 6PLF
TargetD-3-phosphoglycerate dehydrogenase(Human)
Meyer Cancer Center

Curated by ChEMBL
LigandPNGBDBM50512575(CHEMBL4554985)
Affinity DataIC50: 238nMAssay Description:Inhibition of PHGDH (unknown origin) using 140 nM of PHGDH and 3-PG as substrate incubated for 20 mins in presence of NAD+, PSAT1, PSPH by diaphorase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD-3-phosphoglycerate dehydrogenase(Human)
Meyer Cancer Center

Curated by ChEMBL
LigandPNGBDBM50512575(CHEMBL4554985)
Affinity DataIC50: 238nMAssay Description:Inhibition of PHGDH (unknown origin) by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD-3-phosphoglycerate dehydrogenase(Human)
Meyer Cancer Center

Curated by ChEMBL
LigandPNGBDBM50512575(CHEMBL4554985)
Affinity DataIC50: 260nMAssay Description:Inhibition of PHGDH (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD-3-phosphoglycerate dehydrogenase(Human)
Meyer Cancer Center

Curated by ChEMBL
LigandPNGBDBM50512575(CHEMBL4554985)
Affinity DataIC50: 5.70E+4nMAssay Description:Inhibition of human PHGDH by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetD-3-phosphoglycerate dehydrogenase(Human)
Meyer Cancer Center

Curated by ChEMBL
LigandPNGBDBM50512575(CHEMBL4554985)
Affinity DataKi:  214nMAssay Description:Mixed type inhibition of PHGDH (unknown origin) using 3-PG as substrate incubated for 20 mins in presence of , PSAT1, PSPH and varying NAD+ by diapho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)