Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) for PDB: 6QTP
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Angelini

Curated by ChEMBL
LigandPNGBDBM50050549(GSK2140944 | Gepotidacin)
Affinity DataIC50: 47nMAssay Description:Inhibition of Staphylococcus aureus DNA gyraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Angelini

Curated by ChEMBL
LigandPNGBDBM50050549(GSK2140944 | Gepotidacin)
Affinity DataIC50: 47nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase using positively supercoiled pBR322 DNA as substrate incubated for 25 mins by ethidium bromide stainin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Angelini

Curated by ChEMBL
LigandPNGBDBM50050549(GSK2140944 | Gepotidacin)
Affinity DataIC50: 170nMAssay Description:Inhibition of Staphylococcus aureus Gyrase supercoiling activity assessed as reduction in supercoiling pBR322 DNA by measuring relaxation by bromophe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Angelini

Curated by ChEMBL
LigandPNGBDBM50050549(GSK2140944 | Gepotidacin)
Affinity DataIC50: 244nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as reduction in DNA supercoiling using relaxed pNO1 plasmid DNA as substrate incubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Angelini

Curated by ChEMBL
LigandPNGBDBM50050549(GSK2140944 | Gepotidacin)
Affinity DataIC50: 374nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed as reduction in DNA supercoiling using relaxed pNO1 plasmid DNA as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)