Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) for PDB: 6TRX
TargetDipeptidyl peptidase 8(Human)
University of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 8(Human)
University of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 14nMAssay Description:Inhibition of DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 8(Human)
University of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 400nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 8/9(Human)
Tufts College

US Patent
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 1.40E+3nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 8(Human)
University of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 4.00E+5nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 8/9(Human)
Tufts College

US Patent
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50: 1.40E+6nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)