Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) for PDB: 6UDT
LigandPNGBDBM50514214(CHEMBL4542646 | US11274105, Example 41)
Affinity DataIC50: 0.590nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
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Date in BDB:
7/5/2022
Entry Details
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PDB3D3D Structure (crystal)
LigandPNGBDBM50514214(CHEMBL4542646 | US11274105, Example 41)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant C-terminal His6x-tagged human Mcl-1 (171 to 327 residues) interaction with biotinylated human Bim (51 to 76 residues) incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50514214(CHEMBL4542646 | US11274105, Example 41)
Affinity DataIC50: 2.81nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50514214(CHEMBL4542646 | US11274105, Example 41)
Affinity DataIC50: 5.16nMAssay Description:For Mcl-1 TR-FRET assay with 5% human serum, the same assay condition was used except for the addition of 5% human serum (Bioreclamation, Westbury, N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50514214(CHEMBL4542646 | US11274105, Example 41)
Affinity DataIC50: 16.4nMAssay Description:For Mcl-1 TR-FRET assay with 5% human serum, the same assay condition was used except for the addition of 5% human serum (Bioreclamation, Westbury, N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50514214(CHEMBL4542646 | US11274105, Example 41)
Affinity DataKi:  0.0990nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50514214(CHEMBL4542646 | US11274105, Example 41)
Affinity DataKi:  0.100nMAssay Description:Inhibition of recombinant C-terminal His6x-tagged human Mcl-1 (171 to 327 residues) interaction with biotinylated human Bim (51 to 76 residues) incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50514214(CHEMBL4542646 | US11274105, Example 41)
Affinity DataKi:  0.211nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)