Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) for PDB: 6UF0
TargetKelch-like ECH-associated protein 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50120422(CHEMBL3617852)
Affinity DataIC50: 61nMAssay Description:Inhibition of Keap1-Nrf2 (unknown origin) protein-protein interaction expressed in Escherichia coli BL21 codon plus cells using FITC-beta-DEETGEF-OH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM561992(US11396496, Compound B0 | BDBM50537618)
Affinity DataIC50: 73nMAssay Description:Inhibition of FITC-9mer Nrf2 peptide interaction with human recombinant Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli DE3 ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM561992(US11396496, Compound B0 | BDBM50537618)
Affinity DataIC50: 73nMAssay Description:Inhibition of Keap1 kelch domain to Nrf2 (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM561992(US11396496, Compound B0 | BDBM50537618)
Affinity DataIC50: 74nMAssay Description:The IC50 of the compounds for inhibiting the interaction of a fluorescent NRF2 peptide and the Kelch domain of KEAP1 was determined using fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50120422(CHEMBL3617852)
Affinity DataKd:  110nMAssay Description:Inhibition of Keap1-Nrf2 (unknown origin) protein-protein interaction by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50120422(CHEMBL3617852)
Affinity DataIC50: 110nMAssay Description:Binding affinity to the Keap1 (321 to 609 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by surface plasmon resonance assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)