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Report error Found 110 Enz. Inhib. hit(s) for PDB: 6X3X

Gamma-aminobutyric acid receptor subunit alpha-6/beta-2/gamma-2(Rat)
Heidelberg

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 2.10nMAssay Description:Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly,val)beta2gamma2 subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Purchase ChEBI
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Date in BDB:
10/28/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-2(Rat)
Sanofi Synthelabo

Curated by PDSP K_i Database

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 4.80nMMore data for this Ligand-Target Pair

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Date in BDB:
5/2/2012
Entry Details
PubMed PDB

3D Structure (crystal)

GABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 6.60nMAssay Description:Inhibition of [3H]Ro-151788 binding to recombinant human gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 subtype expressed in L (tk-) cellsMore data for this Ligand-Target Pair

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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

GABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 6.60nMAssay Description:Displacement of [3H]-Ro15-1788 from human recombinant GABAA alpha2 in combination with beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair

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Date in BDB:
12/5/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

GABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 6.60nMAssay Description:Binding affinity evaluated by ability to displace [3H]-Ro-15-1788 from recombinant human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 ex...More data for this Ligand-Target Pair

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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP K_i Database

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 7nMMore data for this Ligand-Target Pair

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Date in BDB:
12/27/2011
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-2(Rat)
Sanofi Synthelabo

Curated by PDSP K_i Database

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 7.80nMMore data for this Ligand-Target Pair

PDB
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Date in BDB:
5/2/2012
Entry Details
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-6/beta-2/gamma-2(Rat)
Heidelberg

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 9nMAssay Description:Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly)beta2gamma2 subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Purchase ChEBI
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Date in BDB:
10/28/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2(Human)
Upjohn Laboratories

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 10nMAssay Description:Displacement of [3H]flunitrazepam from GABA-A receptor alpha-3-beta-2-gamma-2 subunits expressed in Sf9 cellsMore data for this Ligand-Target Pair

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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

GABA-A receptor; alpha-5/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 11nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-5-beta-3-gamma-2More data for this Ligand-Target Pair

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Date in BDB:
11/14/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-2(Rat)
University of Firenze

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 11nMAssay Description:Binding affinity for recombinant rat GABA-A receptor alpha-5-beta-3-gamma-2 subunits expressed in HEK 293 cellsMore data for this Ligand-Target Pair

PDB
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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 11nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha5beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair

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Purchase ChEBI
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Date in BDB:
6/23/2023
Entry Details
PubMed PDB

3D Structure (crystal)

GABA-A receptor; alpha-5/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 11nMAssay Description:Displacement of [3H]Ro-151788 from human recombinant GABAA alpha5 in combination with beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair

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Date in BDB:
12/5/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP K_i Database

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 11nMAssay Description:Displacement of [3H]flumazenil from rat GABA-A alpha-1-beta-2-gamma-2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Purchase ChEBI
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Date in BDB:
1/11/2010
Entry Details Article
PubMed PDB

3D Structure (crystal)

GABA-A receptor; alpha-5/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 11nMAssay Description:Inhibition of [3H]Ro-151788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-5-beta-3-gamma-2 subtype expressed in L (tk-) cellsMore data for this Ligand-Target Pair

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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

GABA-A receptor; alpha-5/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 11nMAssay Description:Binding affinity for human GABA-A receptor alpha-5-beta-3-gamma-2 subunits in L(tk-) cellsMore data for this Ligand-Target Pair

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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

GABA-A receptor; alpha-5/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 11.2nMAssay Description:Binding affinity towards human alpha-5-beta-3-gamma-2 GABA-A receptor using [3H]Ro-151788 expressed in L(tk-) cellsMore data for this Ligand-Target Pair

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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP K_i Database

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 12nMMore data for this Ligand-Target Pair

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Date in BDB:
3/2/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 12nMAssay Description:Binding affinity evaluated by ability to displace [3H]Ro-151788 from recombinant human Gamma-aminobutyric acid A receptor alpha-1-beta-2-gamma-2 expr...More data for this Ligand-Target Pair

PDB
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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Università

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 12nMAssay Description:Displacement of [3H]Ro15-1788 from rat recombinant GABA alpha-1-beta-2-gamma-2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB KEGG
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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP K_i Database

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

IC50: 12nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair

PDB
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Date in BDB:
12/5/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 12nMAssay Description:Displacement of [3H]Flumazenil from human GABA-Aalpha1 receptor plus beta-2-gamma-2 expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB
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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
TBA

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 13nMAssay Description:Displacement of [3H]Ro 15-1788 from recombinant human GABAA alpha-1 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair

PDB
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Purchase ChEBI
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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
TBA

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 13nMAssay Description:Inhibition of [3H]Ro-151788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-1-beta-3-gamma-2 subtype expressed in L (tk-) cellsMore data for this Ligand-Target Pair

PDB
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Purchase ChEBI
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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 13nMAssay Description:Displacement of [3H]Flunitrazepam from GABA-A receptor alpha-1-beta-2-gamma-2 subunits expressed in Sf9 cellsMore data for this Ligand-Target Pair

PDB
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Purchase ChEBI
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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
TBA

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 13nMAssay Description:Displacement of [3H]-Ro15-1788 from human recombinant GABAA alpha1 in combination with beta-3-gamma-2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair

PDB
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Date in BDB:
12/5/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2(Rat)
Università

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 13.9nMAssay Description:Displacement of [3H]Ro-151788 from rat GABA-A receptor alpha-3-beta-2-gamma-2 subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Università

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 14nMAssay Description:Displacement of [3H]Ro-151788 from rat GABA-A receptor alpha-1-beta-2-gamma-2 subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB KEGG
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Purchase ChEBI
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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2(Rat)
Università

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 14nMAssay Description:Displacement of [3H]Ro15-1788 from rat recombinant GABA alpha-3-beta-2-gamma-2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB KEGG
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Purchase ChEBI
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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2(Human)
Upjohn Laboratories

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 14nMAssay Description:Displacement of [3H]Flumazenil from human GABA-Aalpha3 receptor plus beta-2-gamma-2 expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB KEGG
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Purchase ChEBI
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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP K_i Database

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 14nMMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
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Purchase ChEBI
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Date in BDB:
5/2/2012
Entry Details
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP K_i Database

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 14nMAssay Description:Displacement of [3H]RO15-1788 from recombinant rat GABAalpha1 receptor expressed in HEK293 cells after 1 hrMore data for this Ligand-Target Pair

PDB
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Purchase ChEBI
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Date in BDB:
5/10/2019
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 14nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha1beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair

PDB
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Purchase ChEBI
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Date in BDB:
6/23/2023
Entry Details
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
TBA

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 14nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-1-beta-3-gamma-2More data for this Ligand-Target Pair

PDB
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Purchase ChEBI
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Date in BDB:
11/14/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Università

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 14nMAssay Description:Binding affinity for recombinant rat GABA-A receptor alpha-1-beta-2-gamma-2 subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB KEGG
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Purchase ChEBI
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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
TBA

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 14nMAssay Description:Displacement of [3H]Ro 15-1788 from human recombinant GABAA alpha-1-beta-3-gamma-2 receptor expressed in L(tk-) cellsMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
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Purchase ChEBI
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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
TBA

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 14nMAssay Description:Binding affinity for human GABA-A receptor alpha-4-beta-3-gamma-2 subunits in L(tk-) cellsMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
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Purchase ChEBI
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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
TBA

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 14.3nMAssay Description:Binding affinity towards human alpha-1-beta-3-gamma-2 GABA-A receptor using [3H]Ro-151788 expressed in L(tk-) cellsMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
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Purchase ChEBI
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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2(Human)
Upjohn Laboratories

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 15nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha3beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair

PDB KEGG
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Purchase ChEBI
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Date in BDB:
6/23/2023
Entry Details
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 15nMAssay Description:Binding affinity for human GABA-A receptor alpha-3-beta-3-gamma-2 subunits in L(tk-) cellsMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
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Purchase ChEBI
CHEMBL DrugBank KEGG PC cid PC sid PDB Similars

Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-2(Rat)
Sanofi Synthelabo

Curated by PDSP K_i Database

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 15nMAssay Description:Displacement of [3H]flumazenil from rat GABA-A alpha-2-beta-2-gamma-2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
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Purchase ChEBI
CHEMBL DrugBank KEGG PC cid PC sid PDB Similars

Date in BDB:
1/11/2010
Entry Details Article
PubMed PDB

3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2(Rat)
Università

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 15nMAssay Description:Binding affinity for recombinant rat GABA-A receptor alpha-3-beta-2-gamma-2 subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Date in BDB:
11/10/2009
Entry Details Article
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3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 15nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-3-beta-3-gamma-2More data for this Ligand-Target Pair

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Date in BDB:
11/14/2012
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3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 15nMAssay Description:Displacement of [3H]Ro 15-1788 from human recombinant GABAA alpha-3-beta-3-gamma-2 receptor expressed in L(tk-) cellsMore data for this Ligand-Target Pair

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Date in BDB:
11/10/2009
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3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1(Human)
University of Sussex

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 16nMAssay Description:Binding affinity to GABA-A alpha1 (unknown origin)More data for this Ligand-Target Pair

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Date in BDB:
2/25/2021
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3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Università

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 16nMAssay Description:Binding affinity for rat GABA-A receptor alpha-1-beta-2-gamma-2 subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Date in BDB:
10/28/2012
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3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1(Human)
University of Sussex

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 16.3nMMore data for this Ligand-Target Pair

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Date in BDB:
11/22/2011
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3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-1(Human)
University of Sussex

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 16.8nMMore data for this Ligand-Target Pair

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Date in BDB:
2/21/2012
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3D Structure (crystal)

Gamma-aminobutyric acid receptor subunit alpha-2(Human)
UniversitÄT Heidelberg

Curated by PDSP K_i Database

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

Ki: 16.9nMMore data for this Ligand-Target Pair

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Date in BDB:
11/22/2011
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3D Structure (crystal)

GABA-A receptor; alpha-5/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL

BDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)

IC50: 17nMAssay Description:Binding affinity to human recombinant GABAA alpha5beta3gamma2 expressed in Xenopus laevis oocytes by patch clamp techniqueMore data for this Ligand-Target Pair

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Date in BDB:
9/24/2013
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3D Structure (crystal)

Displayed 1 to 50 (of 110 total ) | Next | Last >>

Filter my 110 hits

Targets 15▿
- Gamma-aminobutyric acid receptor subunit alpha-1 21
- Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 17
- GABA-A receptor; alpha-2/beta-3/gamma-2 10
- Gamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2 9
- Gamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2 9
- Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 8
- Gamma-aminobutyric acid receptor subunit alpha-2 8
- GABA-A receptor; alpha-5/beta-3/gamma-2 8
- Gamma-aminobutyric acid receptor subunit alpha-6/beta-2/gamma-2 7
- Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 4
- Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2 3
- Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2 2
- Gamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2 2
- Gamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-2 1
- GABA A receptor alpha-4/beta-3/gamma-2 1
- ...
Publications 39▿
- J Med Chem 37: 4576-80 (1995) 8
- J Med Chem 62: 5797-5809 (2019) 6
- Bioorg Med Chem Lett 11: 1573-7 (2001) 6
- Eur J Med Chem 84: 404-16 (2014) 6
- J Med Chem 43: 71-95 (2000) 5
- J Med Chem 47: 1807-22 (2004) 4
- Biochem Pharmacol 55: 209-14 (1998) 4
- J Med Chem 49: 35-8 (2006) 4
- J Med Chem 46: 310-3 (2003) 4
- Bioorg Med Chem Lett 62: (2022) 4
- Mol Pharmacol 52: 1150-6 (1997) 4
- J Med Chem 48: 1367-83 (2005) 4
- Bioorg Med Chem 18: 8374-82 (2010) 4
- J Med Chem 47: 3642-57 (2004) 4
- J Med Chem 39: 158-75 (1996) 3
- Bioorg Med Chem Lett 10: 1381-4 (2000) 3
- J Pharmacol Exp Ther 298: 753-68 (2001) 3
- J Pharmacol Exp Ther 266: 1018-28 (1993) 3
- J Med Chem 48: 7089-92 (2005) 3
- J Med Chem 52: 3723-34 (2009) 2
- Bioorg Med Chem 15: 2573-86 (2007) 2
- J Med Chem 63: 3425-3446 (2020) 2
- Eur J Med Chem 126: 298-352 (2017) 2
- J Med Chem 49: 1235-8 (2006) 2
- Science 245: 1389-92 (1989) 2
- J Med Chem 45: 5710-20 (2002) 2
- J Med Chem 49: 2526-33 (2006) 2
- J Pharmacol Exp Ther 279: 803-12 (1996) 1
- J Med Chem 37: 758-68 (1994) 1
- Bioorg Med Chem 24: 681-5 (2016) 1
- Mol Pharmacol 49: 253-9 (1996) 1
- J Med Chem 51: 3788-803 (2008) 1
- Bioorg Med Chem 23: 6757-62 (2015) 1
- Proc Natl Acad Sci U S A 83: 4918-22 (1986) 1
- J Med Chem 56: 593-624 (2013) 1
- J Med Chem 29: 125-32 (1986) 1
- J Med Chem 48: 6887-96 (2005) 1
- J Med Chem 51: 4430-48 (2008) 1
- J Med Chem 50: 4147-61 (2007) 1
Institutions 26▿
- Merck Sharp and Dohme Research Laboratories 15
- University of Copenhagen 13
- Merck Sharp & Dohme Research Laboratories 9
- University of Wisconsin-Milwaukee 9
- Heidelberg 8
- The Royal Danish School of Pharmacy 6
- Merck Sharp Laboratory 4
- Upjohn Laboratories 4
- Università 4
- University of Firenze 4
- Tokyo Dental College 4
- Astrazeneca Pharmaceuticals 4
- TBA 3
- Georgetown University 3
- Sanofi Synthelabo 3
- University of Kwazulu-Natal 2
- University of Sussex 2
- Universita Di Pisa 2
- Lund University 2
- UniversitÄT Heidelberg 2
- University of Graz 2
- Moltech 1
- Leiden University 1
- Pfizer 1
- University of Urbino 1
- Johannes Gutenberg University 1
Affinity: 2.1 to 8.0E+4 nM▿
- Ki 80
- IC50 3
- Kd 1
- EC50 26
- Affinity ≤ nM
Xtal structures: 2
Docked structures: 0
Catalog Cmpds: 2