Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) for PDB: 6YI8
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM209325(US9266883, 83 | US11136320, Reference Compound)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant His-tagged human FGFR4 expressed in baculovirus expression system using Tyr04 peptide as substrate preincubated in assay bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM209325(US9266883, 83 | US11136320, Reference Compound)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human FGFR4 (447 to 753 residues) incubated for 30 mins in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM209325(US9266883, 83 | US11136320, Reference Compound)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of FGFR4 (unknown origin) incubated for 60 mins by caliper microfluidic mobility shift technology based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4 [388-802](Human)
Novartis

US Patent
LigandPNGBDBM209325(US9266883, 83 | US11136320, Reference Compound)
Affinity DataIC50: 1.90nMpH: 7.5 T: 2°CAssay Description:Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM209325(US9266883, 83 | US11136320, Reference Compound)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of FGFR4 V550L mutant (unknown origin) expressed in Escherichia coli Rosetta2 (DE3) (NEB) cells in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM209325(US9266883, 83 | US11136320, Reference Compound)
Affinity DataIC50: 2.90nMAssay Description:The FGFR4 kinase inhibition of compounds was tested by using mobility shift assay in this experiment, and the rate of FGFR4 kinase inhibition of comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM209325(US9266883, 83 | US11136320, Reference Compound)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of FGFR4 (unknown origin) using Tyr 04 peptide substrate measured after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM209325(US9266883, 83 | US11136320, Reference Compound)
Affinity DataIC50: 9nMAssay Description:Inhibition of FGFR4 V550L mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM209325(US9266883, 83 | US11136320, Reference Compound)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human His-tagged FGFR4 (781 to 1338 residues) cytoplasmic domain expressed in baculovirus expression system using Tyr 04 pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM209325(US9266883, 83 | US11136320, Reference Compound)
Affinity DataIC50: 10nMAssay Description:Inhibition of FGFR4 (unknown origin) expressed in HEK293 cells assessed as reduction in autophosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM209325(US9266883, 83 | US11136320, Reference Compound)
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal 6His-tagged FGFR4 (unknown origin) using Tyr04 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)