Report error Found 4 Enz. Inhib. hit(s) for PDB: 7AVL
Affinity DataKd: 469nMAssay Description:Binding affinity to SOS1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 481nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
Affinity DataIC50: 1.75E+3nMAssay Description:This assay quantifies human SOS1-mediated loading of human K-RasG12C-GDP with a fluorescent GTP-analog. Detection of successful loading is achieved b...More data for this Ligand-Target Pair