Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) for PDB: 7B1P
TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM134354(US8846658, 66)
Affinity DataIC50: 20nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2015
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM134354(US8846658, 66)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant BACE1 catalytic domain using FRET substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM134354(US8846658, 66)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant BACE1 catalytic domain in presence of FRET substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM134354(US8846658, 66)
Affinity DataIC50: 32nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in CHO cells co-expressing human APP751 assessed as decrease in amyloid beta 40 levels after 24 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)