Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) for PDB: 7F3Z
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
National Center for Genetic Engineering and Biotechnology (BIOTEC)

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataKi:  0.590nMAssay Description:Inhibition of wild type Plasmodium falciparum DHFR using DHF as substrate assessed as inhibition constant in presence of NADPH by UV-Vis spectrometry...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
National Center for Genetic Engineering and Biotechnology (BIOTEC)

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Plasmodium falciparum DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
National Center for Genetic Engineering and Biotechnology (BIOTEC)

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataKi:  10.3nMAssay Description:Inhibitory activity against wild-type dihydrofolate reductase (S108N DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
National Center for Genetic Engineering and Biotechnology (BIOTEC)

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataKi:  10.3nMAssay Description:Inhibition of the wild-type dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
National Center for Genetic Engineering and Biotechnology (BIOTEC)

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataKi:  132nMAssay Description:Inhibition of the S108N mutant of dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
National Center for Genetic Engineering and Biotechnology (BIOTEC)

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataKi:  242nMAssay Description:Inhibitory activity against double mutant dihydrofolate reductase (C59R+S108N DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
National Center for Genetic Engineering and Biotechnology (BIOTEC)

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataKi:  242nMAssay Description:Inhibition of the C59R+S108N mutant of dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
National Center for Genetic Engineering and Biotechnology (BIOTEC)

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataKi:  5.69E+3nMAssay Description:Inhibitory activity against triple mutant dihydrofolate reductase (C59R S108 NI164L DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
National Center for Genetic Engineering and Biotechnology (BIOTEC)

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataKi:  6.66E+3nMAssay Description:Inhibitory activity against quadruple mutant dihydrofolate reductase (N51I C59R S108N I164L DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
National Center for Genetic Engineering and Biotechnology (BIOTEC)

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataIC50: 1.37E+5nMAssay Description:Antiplasmodial activity IC50 against Plasmodium falciparum K1CB1 DHFR double-mutant (C59R/S10)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)