Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) for PDB: 7KAF
TargetRNA-directed RNA polymerase catalytic subunit/Polymerase basic protein 1/Polymerase basic protein 2(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Jiaxing Andicon Biotech Co.

US Patent
LigandPNGBDBM50612273(BALOXAVIR | Baloxavir | S-033447 | US12161646, Exa...)
Affinity DataEC50:  0.680nMAssay Description:MDCK cells were seeded in a 96-well cell culture plate, and cultured till cell attachment for later use. The drug was serially 3 times diluted from 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetRNA-directed RNA polymerase catalytic subunit/Polymerase basic protein 1/Polymerase basic protein 2(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Jiaxing Andicon Biotech Co.

US Patent
LigandPNGBDBM50612273(BALOXAVIR | Baloxavir | S-033447 | US12161646, Exa...)
Affinity DataEC50:  1.22nMAssay Description:MDCK cells were seeded in a 96-well cell culture plate, and cultured till cell attachment for later use. The drug was serially 3 times diluted from 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetPolymerase acidic protein(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
South China Agricultural University

Curated by ChEMBL
LigandPNGBDBM50612273(BALOXAVIR | Baloxavir | S-033447 | US12161646, Exa...)
Affinity DataKd:  208nMAssay Description:Inhibition of Escherichia coli FabH expressed in Escherichia coli DH10B cells assessed as incorporation of 3H signal in the product after 25 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRNA-directed RNA polymerase catalytic subunit/Polymerase basic protein 1/Polymerase basic protein 2(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Jiaxing Andicon Biotech Co.

US Patent
LigandPNGBDBM50612273(BALOXAVIR | Baloxavir | S-033447 | US12161646, Exa...)
Affinity DataIC50: 1.14nMAssay Description:2.5 μL of enzymatic reaction mixture (composition: 53 mM Tris hydrochloride (pH 7.8), 1 mM MgCl2, 1.25 mM dithiothreitol, 80 mM NaCl, 12.5% glycerol,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetPolymerase acidic protein(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
South China Agricultural University

Curated by ChEMBL
LigandPNGBDBM50612273(BALOXAVIR | Baloxavir | S-033447 | US12161646, Exa...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of N-terminal His-tagged Escherichia coli FabH expressed in Escherichia coli BL21 (DE3) using [3H]acetyl-coA after 25 mins by liquid scint...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRNA-directed RNA polymerase catalytic subunit/Polymerase basic protein 1/Polymerase basic protein 2(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Jiaxing Andicon Biotech Co.

US Patent
LigandPNGBDBM50612273(BALOXAVIR | Baloxavir | S-033447 | US12161646, Exa...)
Affinity DataIC50: 2.01nMAssay Description:2.5 μL of enzymatic reaction mixture (composition: 53 mM Tris hydrochloride (pH 7.8), 1 mM MgCl2, 1.25 mM dithiothreitol, 80 mM NaCl, 12.5% glycerol,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetPolymerase acidic protein(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
South China Agricultural University

Curated by ChEMBL
LigandPNGBDBM50612273(BALOXAVIR | Baloxavir | S-033447 | US12161646, Exa...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of Influenza A virus CENMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPolymerase acidic protein(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
South China Agricultural University

Curated by ChEMBL
LigandPNGBDBM50612273(BALOXAVIR | Baloxavir | S-033447 | US12161646, Exa...)
Affinity DataIC50: 8.16E+3nMAssay Description:Inhibition of Escherichia coli FabH expressed in Escherichia coli DH10B cells assessed as incorporation of 3H signal in the product after 25 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPolymerase acidic protein(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
South China Agricultural University

Curated by ChEMBL
LigandPNGBDBM50612273(BALOXAVIR | Baloxavir | S-033447 | US12161646, Exa...)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of Escherichia coli FabH expressed in Escherichia coli DH10B cells assessed as incorporation of 3H signal in the product after 25 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details Article
PubMedPDB3D3D Structure (crystal)