Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) for PDB: 7PDQ
TargetRetinoic acid receptor RXR-alpha(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Affinity DataEC50:  4nMAssay Description:Ability to activate gene expression at Retinoic acid receptor RXR-alpha was evaluated in a cotransfection assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Affinity DataEC50:  40nMAssay Description:Activation of human RXRalpha activity expressed in COS1 cells after 12 hrs by RXRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Affinity DataEC50:  17nMAssay Description:In vitro agonistic activity against RXR alpha in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Rat)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Affinity DataEC50:  11nMAssay Description:In vitro transcriptional activation in CV-1 cells expressing RXR-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Affinity DataEC50:  38nMAssay Description:Transcriptional activity against RXR:PPAR-gamma synergy was determined in vitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Affinity DataEC50:  11nMAssay Description:Inhibition of Retinoic acid receptor RXR-alpha agonist activity in vitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Affinity DataKd:  3nMAssay Description:Ability to bind directly to Retinoic acid receptor RXR-alpha was evaluated in a competitive binding assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-beta(Mouse)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Affinity DataEC50:  3nMAssay Description:Ability to activate gene expression at Retinoic acid receptor RXR-beta was evaluated in a cotransfection assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-beta(Mouse)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Affinity DataKd:  3nMAssay Description:Binding affinity to Retinoic acid receptor RXR-beta was determined in a competitive binding assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Rat)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Affinity DataIC50: 5nMAssay Description:In vitro transcriptional activation in CV-1 cells expressing RXR-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Affinity DataIC50: 8nMAssay Description:Transcriptional activation in CV-1 cells expressing Retinoic X receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Affinity DataKi:  3nMAssay Description:Binding affinity against Retinoic acid receptor RXR-alpha by [3H]9-cis-RA displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-beta(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Affinity DataKi:  7.5nMAssay Description:Displacement of [3H]9-cis-RA from Retinoic X receptor betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Affinity DataKi:  13nMAssay Description:Binding affinity against RXR alpha receptor using [3H]9-cis-RA as radioligand in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Affinity DataKi:  18nMAssay Description:Binding affinity against Retinoic acid receptor RXR-alpha was determined in vitro by using [3H]9-cis-RA as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Rat)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Affinity DataKi:  18nMAssay Description:Binding affinity for Retinoic acid receptor RXR-alpha was determined by competing with 3[H]-9-cis-RAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-beta(Rat)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Affinity DataKi:  20nMAssay Description:Binding affinity for Retinoic acid receptor RXR-beta was determined by competing with 3[H]-9-cis-RAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-beta(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Affinity DataKi:  75nMAssay Description:Displacement of [3H]9-cis-RA from RXR beta receptor in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-beta(Mouse)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Affinity DataKi:  3.52E+3nMAssay Description:Binding affinity against retinoic acid receptor beta by [3H]ATRA displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)