Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) for PDB: 7RC9
TargetToll-like receptor 8(Human)
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM21958(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at R848 stimulated human TRL8 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincubated wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM21958(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...)
Affinity DataIC50: 3.20nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM21958(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...)
Affinity DataIC50: 4.20nMAssay Description:Antagonist activity at R848 stimulated TRL8 in human whole blood assessed as inhibition of IL-6 production by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)