Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) for PDB: 7UH8
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058855(CHEMBL64267 | CHEMBL23743 | (S)-2-Butoxycarbonylam...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of [125I]fibrinogen binding to purified platelet Fibrinogen ReceptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058855(CHEMBL64267 | CHEMBL23743 | (S)-2-Butoxycarbonylam...)
Affinity DataIC50: 0.25nMAssay Description:Affinity for purified human platelet glycoprotein alpha IIb beta3 integrin receptor in ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058855(CHEMBL64267 | CHEMBL23743 | (S)-2-Butoxycarbonylam...)
Affinity DataIC50: 11nMAssay Description:Inhibition of [125I]fibrinogen binding to activated human plateletsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058855(CHEMBL64267 | CHEMBL23743 | (S)-2-Butoxycarbonylam...)
Affinity DataIC50: 21nMAssay Description:Inhibition of fibrinogen (Fg) interaction with GPIIb/IIIa in gel filtered plateletsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058855(CHEMBL64267 | CHEMBL23743 | (S)-2-Butoxycarbonylam...)
Affinity DataIC50: 50nMAssay Description:In vitro inhibition of ADP-induced platelet aggregation in human platelet rich plasma (hPRP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058855(CHEMBL64267 | CHEMBL23743 | (S)-2-Butoxycarbonylam...)
Affinity DataIC50: 50nMAssay Description:Inhibition of platelet aggregation in citreated human platelet rich plasma (PRP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058855(CHEMBL64267 | CHEMBL23743 | (S)-2-Butoxycarbonylam...)
Affinity DataIC50: 60nMAssay Description:In vitro inhibition of gel filtered platelet aggregation induced by ADP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058855(CHEMBL64267 | CHEMBL23743 | (S)-2-Butoxycarbonylam...)
Affinity DataIC50: 66nMAssay Description:Inhibition of platelet aggregation in heparin treated human platelet rich plasma (PRP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)