Report error Found 6 Enz. Inhib. hit(s) for PDB: 7UKS
Affinity DataKi: 0.110nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 0.330nMAssay Description:Binding affinity to SOS1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 0.330nMAssay Description:Binding affinity to SOS1 (unknown origin) assessed as inhibition constant by HTRF methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.330nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 0.430nMAssay Description:Binding affinity to human recombinant SOS1 assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Table 24: This Example illustrates that exemplary compounds of the present invention prevent KRas-mediated GTP nucleotide exchange mediated by SOS1 t...More data for this Ligand-Target Pair