Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) for PDB: 7WRF
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50241426(3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...)
Affinity DataIC50: 58nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50241426(3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...)
Affinity DataEC50:  60nMAssay Description:Activation of TRPM8 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50241426(3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...)
Affinity DataEC50:  110nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50241426(3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...)
Affinity DataEC50:  190nMAssay Description:Agonist activity at rat recombinant TRPM8 receptor expressed in HEK293 cells assessed as increase in intracellular calcium concentration by fluorimet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50241426(3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...)
Affinity DataEC50:  300nMAssay Description:Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50241426(3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...)
Affinity DataEC50:  300nMAssay Description:Agonist activity at human recombinant TRPM8More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)