Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) for PDB: 7Z2E
TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
Fudan University

Curated by ChEMBL
LigandPNGBDBM222178(Rilpivirine)
Affinity DataEC50:  0.800nMAssay Description:Inhibition of HIV RT K103N/Y181C mutant by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM222178(Rilpivirine)
Affinity DataEC50:  0.400nMAssay Description:Inhibition of wild type HIV-1 reverse transcriptase assessed as reduction in luciferase reporter activity by single-round assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM222178(Rilpivirine)
Affinity DataIC50: 15nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase assessed as reduction in biotin-dUTP incorporation into protein incubated for 1 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM222178(Rilpivirine)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant wild type p66/p51 HIV1 reverse transcriptase incubated for 40 mins by picogreen dye-based spectrofluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM222178(Rilpivirine)
Affinity DataIC50: 22nMAssay Description:Inhibition of wild type HIV1 p66/p51 reverse transcriptase using poly(rA) as template, oligo(dT)16 as primer and RNA/DNA as substrate measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM222178(Rilpivirine)
Affinity DataIC50: 38nMAssay Description:Covalent inhibition of recombinant wild type HIV-1 reverse transcriptase using poly(rA)350/oligo(dT)16 as template/primer preincubated followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGag-Pol polyprotein(HIV-1)
Jaipur National University

LigandPNGBDBM222178(Rilpivirine)
Affinity DataIC50: 68nMT: 2°CAssay Description:To a lysis buffer (20 μl), 4-6 ng recombinant HIV-1-RT was added in separate reaction tubes. Lysis buffer without HIV-1-RT was used as a negative ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM222178(Rilpivirine)
Affinity DataIC50: 160nMAssay Description:Inhibition of HIV1 Reverse transcriptase incubated for 30 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM222178(Rilpivirine)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HIV1 reverse transcriptase RNase H using 18-nucleotide 3'-fluorescein-labeled RNA/5'-dabcyl-labeled DNA hybrid as substrate measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)