Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) for PDB: 8AKE
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM27507(pyridine-3-carboxamide | nicotinamide | 3-Pyridine...)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of human SIRT6 demyristoylation reaction assessed as deacylation using H3K9 decanoyl peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM27507(pyridine-3-carboxamide | nicotinamide | 3-Pyridine...)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of full length GST-tagged SIRT6 (unknown origin) assessed as demyristoylation using acyl substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM27507(pyridine-3-carboxamide | nicotinamide | 3-Pyridine...)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of recombinant human N-terminal polyhis-tagged SIRT6 (1 to 355 residues) defatty-acylase activity expressed in Escherichia coli using SFP3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM27507(pyridine-3-carboxamide | nicotinamide | 3-Pyridine...)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of full length GST-tagged SIRT6 (unknown origin) assessed as de-octanoylation using acyl substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM27507(pyridine-3-carboxamide | nicotinamide | 3-Pyridine...)
Affinity DataIC50: 1.53E+5nMAssay Description:Inhibition of SIRT6 (unknown origin) deacylation using fluorogenic substrate AcEALPK(MyrK)-AMC by HPLC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM27507(pyridine-3-carboxamide | nicotinamide | 3-Pyridine...)
Affinity DataIC50: 1.84E+5nMAssay Description:Inhibition of SIRT6 (unknown origin) using AMC containing peptide substructure by fluorogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM27507(pyridine-3-carboxamide | nicotinamide | 3-Pyridine...)
Affinity DataIC50: 1.84E+5nMAssay Description:Inhibition of SIRT6 (unknown origin) deacylation using fluorogenic substrate AcEALPK(MyrK)-AMC by fluorogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM27507(pyridine-3-carboxamide | nicotinamide | 3-Pyridine...)
Affinity DataIC50: 1.84E+5nMAssay Description:Inhibition of human SIRT6 demyristoylation reaction assessed as deacylation using H3K9 hexanoyl-peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM27507(pyridine-3-carboxamide | nicotinamide | 3-Pyridine...)
Affinity DataIC50: 1.89E+5nMAssay Description:Inhibitory constants (Ki) and IC50 values were determined under saturating substrate conditions by using a fluorimetric assay (components were purcha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM27507(pyridine-3-carboxamide | nicotinamide | 3-Pyridine...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of SIRT6 (unknown origin) using (DABCYL)ISGASE(MyK)DIVHSE(EDANS)G substrate in presence of NAD followed by 1 hr incubation with trypsin by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)