Report error Found 17 Enz. Inhib. hit(s) for PDB: 8EIQ
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 3nMAssay Description:Corrector activity at CFTR mutant (unknown origin) by phenotypic screening assayMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 12nMAssay Description:Potentiator activity at CFTR F508del mutant (unknown origin) expressed in CFBE41o cells assessed as increase in forskolin induced transepithelial sho...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 13nMAssay Description:Corrector activity at CFTR F508del mutant in forskolin-stimulated human bronchial epithelial cells derived from primary CF assessed as increase in me...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 22nMAssay Description:Potentiation of human CFTR F508del/G551D mutant in human bronchial epithelial cells by Ussing chambers recording techniqueMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 25nMAssay Description:Inhibition of CFTR F508 deletion mutant (unknown origin)More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 34nMAssay Description:Potentiation of wild type CFTR (unknown origin) expressed in HBE cells assessed as change in short circuit current in presence of forskolin and amilo...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 49nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin) expressed in FRT cells assessed as chloride transport by measuring membrane potential in presenc...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 68nMAssay Description:Potentiation of CFTR F508 deletion mutant (unknown origin) expressed in HBE cells assessed as change in short circuit current in presence of forskoli...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 70nMAssay Description:Potentiation of wild-type CFTR (unknown origin) expressed in FRT cells assessed as chloride transport by measuring membrane potential in presence of ...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 100nMAssay Description:Inhibition of CFTR G551D mutant (unknown origin)More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 131nMAssay Description:Potentiation of CFTR G551D mutant (unknown origin) expressed in FRT cells assessed as chloride transport by measuring membrane potential in presence ...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 236nMAssay Description:Corrector activity at human bronchial epithelium CFTR F508del and G551D mutant assessed as increase in channel gatingMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 236nMAssay Description:Potentiation of human CFTR F508del mutant in human bronchial epithelial cells by Ussing chambers recording techniqueMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 272nMAssay Description:Single-Channel Recordings activity of wt-CFTR and temperature-corrected ΔF508-CFTR expressed in NIH3T3 cells was observed using excised inside-o...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL