Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) for PDB: 8ETR
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS and nigericin-stimulated human PBMC cells assessed as reduction in IL-1beta release preincubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50: 16nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated human monocyte-derived macrophage assessed as reduction in ILbeta secretion in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50: 17nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated human monocyte-derived macrophage assessed as reduction in ILbeta secretion in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50: 17nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated human monocyte-derived macrophage assessed as reduction in IL-18 secretion in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50: 17nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated human monocyte-derived macrophage assessed as reduction in IL-18 secretion in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50: 48nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS/nigericin stimulated human THP1-ASC-GFP cells assessed as decrease in ASC speck formation preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50: 51nMAssay Description:Inhibition of NLRP3 induced caspase 1 activity in LPS/nigericin-treated human THP-1 cells preincubated with LPS for 3 hrs followed by compound additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50: 51nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in caspase-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50: 63nMAssay Description:Inhibition of NLRP3 in human BMDM cells assessed as reduction in caspase-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50: 290nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated human whole blood assessed as reduction in ILbeta secretion in presence of calcium pyro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50: 380nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated human whole blood assessed as reduction in ILbeta secretion in presence of monosodium u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50: 400nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS and ATP-stimulated human whole blood assessed as reduction in IL-1beta release in plasma preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50: 490nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated human whole blood assessed as reduction in ILbeta secretion in presence of cholesterol ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)