Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) for PDB: 8FD7
TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50080153(CHEMBL940 | [1-(AMINOMETHYL)CYCLOHEXYL]ACETIC ACID...)
Affinity DataIC50: 27nMAssay Description:Binding affinity towards alpha2-delta subunit of a voltage gated calcium channel using [3H]gabapentin in human brain membrane (A710 membrane)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50080153(CHEMBL940 | [1-(AMINOMETHYL)CYCLOHEXYL]ACETIC ACID...)
Affinity DataIC50: 70nMAssay Description:Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50080153(CHEMBL940 | [1-(AMINOMETHYL)CYCLOHEXYL]ACETIC ACID...)
Affinity DataIC50: 140nMAssay Description:Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50080153(CHEMBL940 | [1-(AMINOMETHYL)CYCLOHEXYL]ACETIC ACID...)
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of potassium-evoked [3H]norepinephrine release from rat neocortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50080153(CHEMBL940 | [1-(AMINOMETHYL)CYCLOHEXYL]ACETIC ACID...)
Affinity DataKi:  120nMAssay Description:Displacement of [3H]L-leucine from alpha-2delta containing calcium channel in murine brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)