Report error Found 95 Enz. Inhib. hit(s) for PDB: 8FYX
Displayed 1 to 50 (of 95 total ) | Next | Last >>
Affinity DataKi: 3.10nMAssay Description:Binding affinity at 5-hydroxytryptamine 1A receptor in bovine hippocampal preparation using [3H]8-OH-DPATMore data for this Ligand-Target Pair
3D Structure (crystal)Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 3.80nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in rat hippocampal membranesMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Binding affinity to 5HT1A receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 4.80nMAssay Description:Binding affinity to 5-HT1A (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...More data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5-HT1A receptor stably expressed in CHO-K1 cell membranes measured after 60 mins by Microbeta2 scintillation...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Binding affinity was determined against 5-hydroxytryptamine 1A receptor using [3H]WB-4101More data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Displacement of [3H]-8-OH-DAPT from human 5-HT1A receptor expressed in CHO-K1 cells membrane by scintillation counter analysisMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Displacement of [3H]8-OH-DPAT from recombinant human 5HT1A receptor stably expressed in CHO-K1 cell membranes measured after 60 mins by microbeta2 sc...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor by displacing [3H]WB-4101 from rat hippocampusMore data for this Ligand-Target Pair
Affinity DataKi: 6.60nMAssay Description:Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 7nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat hippocampal membranesMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 7.10nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor using receptor binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 8.60nMAssay Description:Binding affinity of compound towards 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT (0.5 nM) ligand in hippocampus + frontal bovine was determin...More data for this Ligand-Target Pair
Affinity DataKi: 8.90nMAssay Description:Agonist activity at 5HT1A receptor (unknown origin)More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 9.30nMAssay Description:Binding affinity against rat 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 10nMAssay Description:Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 10nMAssay Description:In vitro ability to inhibit [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat hippocampusMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 10nMAssay Description:In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor of rat hippocampus with [3H]8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibitory concentration against 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hrMore data for this Ligand-Target Pair
Affinity DataKi: 12nM ΔG°: -45.2kJ/moleT: 2°CAssay Description:The composition of the assay buffers was as follows: for 5-HT1AR: 50 mM Tris HCl, 0.1 mM EDTA, 4 mM MgCl2, 10 lM pargyline, and 0.1% ascorbate; for 5...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 12.3nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in the rat brain (hippocampus) using [3H]8-OH-DPATMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 12.8nMAssay Description:In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 12.8nMAssay Description:In vitro ability to inhibit binding of radioligand [3H]8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 13nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 14nMAssay Description:Inhibitory affinity constant against 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 15nMAssay Description:Binding affinity against rat hippocampal 5-hydroxytryptamine 1A (5-HT1A) receptor determined using [3H]8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 15nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampusMore data for this Ligand-Target Pair
Affinity DataEC50: 15nMAssay Description:Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in ERK1/2 phosphorylation levels i...More data for this Ligand-Target Pair
Affinity DataEC50: 15nMAssay Description:Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in ERK1/2 phosphorylation after 15 mins by Alp...More data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Binding affinity against human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 15nMAssay Description:Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brainMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 15nMAssay Description:Binding affinity by measuring displacement of [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampusMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 15.4nMAssay Description:In vitro ability to displace [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor sites of rat brain cortex.More data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Affinity for 5HT1A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5-HT1A expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand bi...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacementMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5HT1AR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Institute of Pharmacology of The Polish Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5-HT1AR in rat hippocampusMore data for this Ligand-Target Pair