Report error Found 15 Enz. Inhib. hit(s) for PDB: 8GMB
Affinity DataKd: 0.350nMAssay Description:Binding affinity to full length BTK (unknown origin) assessed as dissociation constant measured at 37 degree C by TR-FRET assayMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 0.900nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.910nMAssay Description:Inhibition of human recombinant C-terminal polyhistidine tagged BTK (1 to 659 residues)-mediated synthetic peptide substrate phosphorylation expresse...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of BTK in human isolated primary B cells assessed as inhibition of anti-IgM-induced cell proliferation by [3H]thymidine incorporation assa...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of BTK in human mononuclear cell-derived monocytes assessed as inhibition of FCgammaR3 activation-induced TNFalpha production by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of BTK in human isolated primary B cells assessed as inhibition of CD40L-induced cell proliferation by [3H]thymidine incorporation assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Inhibition of BTK C481S mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in autophosphorylation at Y223 residue incubated for 1 hr by mesoscale assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMAssay Description:Inhibition of anti-IgM-induced BTK phosphorylation at Y233 in human primary B cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of BTK in human whole blood-derived CD19+ B cells assessed as suppression of anti-IgM stimulated-CD69 expression preincubated for 1 hr fol...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in anti-IgM-stimulated CD69 expression preincubated for 1 hr followed by goat F(ab')2 an...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of anti-IgM-induced BTK phosphorylation at Y233 in human whole blood after 6 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of BTK in HEK293 cells using NanoGlo substrate incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of BTK in human whole blood derived-basophils assessed as suppression of IgE mediated-FcepsilonR ligation-stimulated CD63 expressionMore data for this Ligand-Target Pair