Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) for PDB: 8PVB
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125935(CHEMBL681 | R(+)-etomidate | Amidate | (R)-1-(1-ph...)
Affinity DataEC50:  1.20E+3nMAssay Description:Ability to enhance currents from alpha-1-beta-2-gamma-2L-subunit of GABA receptor elicited by low concentrations of GABAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125935(CHEMBL681 | R(+)-etomidate | Amidate | (R)-1-(1-ph...)
Affinity DataEC50:  6.40E+4nMAssay Description:Direct activation of Gamma-aminobutyric acid A receptor in the absence of GABAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125935(CHEMBL681 | R(+)-etomidate | Amidate | (R)-1-(1-ph...)
Affinity DataEC50:  2.50E+3nMAssay Description:Enhancement of currents elicited by GABA at EC5 (6-12 uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50125935(CHEMBL681 | R(+)-etomidate | Amidate | (R)-1-(1-ph...)
Affinity DataEC50:  3.50E+3nMAssay Description:Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125935(CHEMBL681 | R(+)-etomidate | Amidate | (R)-1-(1-ph...)
Affinity DataIC50: 5.77E+5nMAssay Description:Inhibition of currents elicited by GABA at EC5 (6-12 uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)