Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) for PDB: 8S9C
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003659(5H-dibenzo[b,f]azepine-5-carboxamide | TEGRETOL | ...)
Affinity DataIC50: 2.20E+4nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003659(5H-dibenzo[b,f]azepine-5-carboxamide | TEGRETOL | ...)
Affinity DataIC50: 9.13E+4nMAssay Description:Inhibition of human Nav1.7 at -60 mV holding potential by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003659(5H-dibenzo[b,f]azepine-5-carboxamide | TEGRETOL | ...)
Affinity DataKi:  3.27E+4nMAssay Description:Inhibition of Nav1.7 (unknown origin) by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)