Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) for PDB: 8SZF
TargetExtracellular calcium-sensing receptor(Human)
Acadia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50416875(CINACALCET | AMG-073 | AMG073 HCL | CINACALCET HYD...)
Affinity DataEC50:  19.9nMAssay Description:Positive allosteric modulation of calcium sensing receptor by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetExtracellular calcium-sensing receptor(Human)
Acadia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50416875(CINACALCET | AMG-073 | AMG073 HCL | CINACALCET HYD...)
Affinity DataEC50:  80nMAssay Description:Positive allosteric modulation of human CaSR transfected in CHO cells after 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetExtracellular calcium-sensing receptor(Human)
Acadia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50416875(CINACALCET | AMG-073 | AMG073 HCL | CINACALCET HYD...)
Affinity DataEC50:  180nMAssay Description:Agonist activity at human CaSR expressed in CHO cells assessed as increase in intracellular calcium mobilization after 1 hr by Fura-2 dye-based fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)