Compile Data Set for Download or QSAR
Report error Found 537 of affinity data for UniProtKB/TrEMBL: O00411
TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784179BDBM784179(2-((R)-1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydroiso...)
Affinity DataIC50: 9nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 782944BDBM782944(ethyl N-methyl-N-(2-oxo-4-(o-tolyl)-2H-chromen-7-y...)
Affinity DataIC50: 20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 782943BDBM782943(isopropyl N-methyl-N-(2-oxo-4-(o-tolyl)-2H-chromen...)
Affinity DataIC50: 20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784185BDBM784185(1-(1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydroisoquin...)
Affinity DataIC50: 20nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784197BDBM784197(3-ethyl-1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydrois...)
Affinity DataIC50: 20nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784202BDBM784202((R)-4-(2-((4-(3-fluoro-2-methylphenyl)-1-oxo-1,2-d...)
Affinity DataIC50: 20nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784188BDBM784188(2-methyl-2-(1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihyd...)
Affinity DataIC50: 20nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 782945BDBM782945(methyl N-methyl-N-(2-oxo-4-(o-tolyl)-2H-chromen-7-...)
Affinity DataIC50: 30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 783007BDBM783007(7-((isoxazol-3-ylmethyl)(methyl)amino)-4-(o-tolyl)...)
Affinity DataIC50: 30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784201BDBM784201((R)-4-(2-((4-(4-fluoro-2-methylphenyl)-1-oxo-1,2-d...)
Affinity DataIC50: 30nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 782877BDBM782877((S)-1-(N-methyl-N-(2-oxo-4-(o-tolyl)-2H-chromen-7-...)
Affinity DataIC50: 30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784107BDBM784107(1-(1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydroisoquin...)
Affinity DataIC50: 30nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784148BDBM784148(1-(1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydroisoquin...)
Affinity DataIC50: 30nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 703432BDBM703432(US20240368106, Example 106)
Affinity DataIC50: 30nMAssay Description:Proteins used as transcription factors (POLRMT: NP_005026.3, TFAM: NP_003192.1, TFB2M: NP_071761.1) are diluted from their stocks to working concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 703433BDBM703433(US20240368106, Example 107)
Affinity DataIC50: 30nMAssay Description:Proteins used as transcription factors (POLRMT: NP_005026.3, TFAM: NP_003192.1, TFB2M: NP_071761.1) are diluted from their stocks to working concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784190BDBM784190(2-methyl-2-(1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihyd...)
Affinity DataIC50: 30nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 782930BDBM782930(2,2-dimethyl-3-(methyl(2-oxo-4-(o-tolyl)-2H-chrome...)
Affinity DataIC50: 30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784198BDBM784198(3-ethyl-1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydrois...)
Affinity DataIC50: 40nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784184BDBM784184(2-((S)-1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydroiso...)
Affinity DataIC50: 40nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 782910BDBM782910(N-methyl-N-(2-oxo-4-(o-tolyl)-2H-chromen-7-yl)-D-a...)
Affinity DataIC50: 40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784210BDBM784210(1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydroisoquinoli...)
Affinity DataIC50: 40nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784191BDBM784191(2-methyl-2-(1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihyd...)
Affinity DataIC50: 40nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 782872BDBM782872(tert-butyl N-methyl-N-(2-oxo-4-(o-tolyl)-2H-chrome...)
Affinity DataIC50: 40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 703431BDBM703431(US20240368106, Example 105)
Affinity DataIC50: 40nMAssay Description:Proteins used as transcription factors (POLRMT: NP_005026.3, TFAM: NP_003192.1, TFB2M: NP_071761.1) are diluted from their stocks to working concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784186BDBM784186(1-(1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydroisoquin...)
Affinity DataIC50: 40nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784175BDBM784175(1-(1-((R)-2-((4-(2-chloro-4-fluorophenyl)-1-oxo-1,...)
Affinity DataIC50: 50nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 782848BDBM782848(Synthesis of (R)-4-(2-chloro-4-fluorophenyl)-7-(me...)
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 782928BDBM782928(7-(benzylamino)-4-(o-tolyl)-2H-chromen-2-one | US2...)
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 782847BDBM782847(Synthesis of (R)-4-(2-chloro-4-fluorophenyl)-7-(me...)
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 703370BDBM703370(US20240368106, Example 42)
Affinity DataIC50: 50nMAssay Description:Proteins used as transcription factors (POLRMT: NP_005026.3, TFAM: NP_003192.1, TFB2M: NP_071761.1) are diluted from their stocks to working concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 783852BDBM783852(5,5-difluoro-1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihy...)
Affinity DataIC50: 50nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 782999BDBM782999(2-(methyl(2-oxo-4-(o-tolyl)-2H-chromen-7-yl)amino)...)
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 782982BDBM782982(7-(((1H-pyrazol-5-yl)methyl)(methyl)amino)-4-(o-to...)
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 782981BDBM782981(N-methyl-2-(methyl(2-oxo-4-(o-tolyl)-2H-chromen-7-...)
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 783850BDBM783850(5,5-difluoro-1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihy...)
Affinity DataIC50: 60nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784195BDBM784195(2-(1-((R)-2-((4-(2-chloro-4-fluorophenyl)-1-oxo-1,...)
Affinity DataIC50: 60nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 783917BDBM783917((R)-4-methyl-1-(2-((1-oxo-4-(o-tolyl)-1,2-dihydroi...)
Affinity DataIC50: 60nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 782885BDBM782885((S)-1-(2-methyl-3-(2-oxo-4-(o-tolyl)-2H-chromen-7-...)
Affinity DataIC50: 60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 783866BDBM783866(methyl 2-(1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydro...)
Affinity DataIC50: 60nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784189BDBM784189(2-methyl-2-(1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihyd...)
Affinity DataIC50: 60nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 783869BDBM783869(methyl 2-(1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydro...)
Affinity DataIC50: 70nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 782857BDBM782857((R)-4-(2-chloro-4-fluorophenyl)-7-(methyl(1-morpho...)
Affinity DataIC50: 70nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784036BDBM784036((R)-1-(1-(2-((1-oxo-4-(o-tolyl)-1,2-dihydroisoquin...)
Affinity DataIC50: 70nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784214BDBM784214(4-(2-(hydroxymethyl)-6-methylphenyl)-7-(2,2,2-trif...)
Affinity DataIC50: 80nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 782864BDBM782864(7-(2-methyl-3-oxo-3-(piperidin-1-yl)propyl)-4-(o-t...)
Affinity DataIC50: 80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 782992BDBM782992(7-(methyl(oxazol-2-ylmethyl)amino)-4-(o-tolyl)-2H-...)
Affinity DataIC50: 80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784217BDBM784217((R)-4-(2-((4-(2-(methyl-d3)phenyl)-1-oxo-1,2-dihyd...)
Affinity DataIC50: 80nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784149BDBM784149(1-(1-((R)-2-((4-(2-chloro-4-fluorophenyl)-1-oxo-1,...)
Affinity DataIC50: 80nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 724637BDBM724637(US20250066377, Example 23)
Affinity DataIC50: 90nMAssay Description:The ability of some compounds of the present invention to inhibit POLRMT were determined in a homogeneous TR-FRET Assay using high-throughput screeni...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 703420BDBM703420(US20240368106, Example 94)
Affinity DataIC50: 90nMAssay Description:Proteins used as transcription factors (POLRMT: NP_005026.3, TFAM: NP_003192.1, TFB2M: NP_071761.1) are diluted from their stocks to working concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

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