Compile Data Set for Download or QSAR
Report error Found 30 for UniProtKB: O15399
TargetGlutamate receptor ionotropic, NMDA 1/2D(Human)
Sage Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597430BDBM50597430(Dalzanemdor | DALZANEMDOR)
Affinity DataEC50:  430nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2D receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2D(Human)
Sage Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50498430BDBM50498430(CHEMBL3594112)
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant GluN1/GluN2D receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of glutamate-evoked current by whol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50503153BDBM50503153(CHEMBL4544421)
Affinity DataIC50: 1.40E+3nMAssay Description:Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50503149BDBM50503149(CHEMBL4464605)
Affinity DataIC50: 2.40E+3nMAssay Description:Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50440056BDBM50440056(CHEMBL2333944)
Affinity DataIC50: 2.70E+3nMAssay Description:Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50503146BDBM50503146(CHEMBL4447266)
Affinity DataIC50: 2.70E+3nMAssay Description:Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50440056BDBM50440056(CHEMBL2333944)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of NMDA GluN2D receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50436060BDBM50436060(CHEMBL2397100 | US10273214, Example 1390)
Affinity DataEC50:  2.80E+3nMAssay Description:Positive allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324401BDBM50324401((E)-4-(6-Methoxy-2-(3-nitrostyryl)-4-oxoquinazolin...)
Affinity DataIC50: 3.90E+3nMAssay Description:Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50611444BDBM50611444(CHEMBL5273123)
Affinity DataEC50:  5.10E+3nMAssay Description:Positive allosteric modulator activity at GluN2D NMDA receptor (unknown origin) expressed in CHO cells co-expressing GluN1a in the presence of L-glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2D(Human)
Sage Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50164398BDBM50164398(CHEMBL3799213)
Affinity DataEC50:  6.20E+3nMAssay Description:Positive allosteric modulation of GluN1/GluN2D NMDAR (unknown origin) expressed in Dox-inducible cells by BD calcium indicator dye based-fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50503147BDBM50503147(CHEMBL4435232)
Affinity DataEC50:  6.70E+3nMAssay Description:Positive allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2D(Human)
Sage Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205849BDBM50205849(CHEMBL3938522 | US10280165, Example 1)
Affinity DataEC50:  9.50E+3nMAssay Description:Positive allosteric modulation of GluN1/GluN2D receptor (unknown origin) assessed as increase in glutamate-induced calcium flux measured at time inte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2D(Human)
Sage Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 409486BDBM409486(N-Cyclopropyl-2-[6-[3-(trifluoromethyl)phenyl]pyrr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2D expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2D(Human)
Sage Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 436689BDBM436689(US10617676, Example 20 | N-Cyclopropyl-2-[2-oxo-6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2D expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 276559BDBM276559(US10071988, Example 499 | 2-[[1-[3-(Difluoromethox...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human GluN2D receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616996BDBM50616996(CHEMBL5416465)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human GluN2D receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 276103BDBM276103(2-[[1-[4-Chloro-3-(difluoromethoxy)phenyl]triazol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human GluN2D receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50379184BDBM50379184(CHEMBL2010868)
Affinity DataEC50:  1.00E+4nMAssay Description:Positive allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50236939BDBM50236939(CHEMBL2333945)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of human GluN2D receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel cur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50498439BDBM50498439(CHEMBL1179566)
Affinity DataIC50: 1.40E+4nMAssay Description:Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50503152BDBM50503152(CHEMBL4452216)
Affinity DataEC50:  2.90E+4nMAssay Description:Positive allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2D(Human)
Sage Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599751BDBM50599751(CHEMBL5092058)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulator activity at GluN1a/GluN2D (unknown origin) expressed in CHO cells in presence of glutamate by Ca2+ influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50236939BDBM50236939(CHEMBL2333945)
Affinity DataIC50: 3.00E+4nMAssay Description:Negative allosteric modulation of human GluN2D receptor expressed in HEK cells assessed as reduction in glycine/glutamate-induced intracellular calci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50503145BDBM50503145(CHEMBL4456824)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50083351BDBM50083351(4-(2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl)phen...)
Affinity DataIC50: 7.59E+4nMAssay Description:Negative allosteric modulation of human GluN2D receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel cur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50503144BDBM50503144(CHEBI:35420 | CHEMBL1179605)
Affinity DataEC50:  7.80E+4nMAssay Description:Positive allosteric modulation of EGFP-fused human GluN2D receptor expressed in HEK293T cells assessed as increase in glycine-induced channel current...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50503144BDBM50503144(CHEBI:35420 | CHEMBL1179605)
Affinity DataIC50: 1.18E+5nMAssay Description:Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50259886BDBM50259886(CHEMBL2333943)
Affinity DataIC50: 4.26E+5nMAssay Description:Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2D(Human)
Sage Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50259886BDBM50259886(CHEMBL2333943)
Affinity DataIC50: 4.26E+5nMAssay Description:Negative allosteric modulation of GluN1a/GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glutamate/glyc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed