TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human His-tagged IRE1alpha expressed in Sf9 insect cells preincubated for 1 hr followed by Alexa fluor 647-labeled probe addition and m...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.0500nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.0800nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of human His-tagged IRE1alpha expressed in Sf9 insect cells preincubated for 1 hr followed by Alexa fluor 647-labeled probe addition and m...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.0900nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of human His-tagged IRE1alpha expressed in Sf9 insect cells preincubated for 1 hr followed by Alexa fluor 647-labeled probe addition and m...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human His-tagged IRE1alpha expressed in Sf9 insect cells preincubated for 1 hr followed by Alexa fluor 647-labeled probe addition and m...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.100nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.100nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.100nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.100nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.100nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.100nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.100nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.100nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.100nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human His-tagged IRE1alpha expressed in Sf9 insect cells preincubated for 1 hr followed by Alexa fluor 647-labeled probe addition and m...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.100nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.100nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.110nMAssay Description:Inhibition of human His-tagged IRE1alpha expressed in Sf9 insect cells preincubated for 1 hr followed by Alexa fluor 647-labeled probe addition and m...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.110nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.110nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.110nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.120nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.120nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.120nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.120nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.120nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.130nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.130nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.130nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.130nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.130nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.130nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.130nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.130nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.140nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.140nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.140nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.140nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.140nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.140nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.140nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.150nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.150nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.150nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell
Curated by ChEMBL
Smith, Gambrell & Russell
Curated by ChEMBL
Affinity DataIC50: 0.150nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.150nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.160nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE 1 [547-977,D688N](Human)
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 0.160nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair












































