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TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98601BDBM98601((2S)-6-[[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)...)
Affinity DataKi:  4.70nM ΔG°:  -47.4kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98599BDBM98599((2S)-6-amino-2-[[(2R)-2-(benzylsulfonylamino)-3-hy...)
Affinity DataKi:  6.80nM ΔG°:  -46.5kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98587BDBM98587((2R)-N-[(1S)-1-(benzyloxymethyl)-2-[(4-carbamimido...)
Affinity DataKi:  6.80nM ΔG°:  -46.5kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98600BDBM98600((2S)-2-[[(2R)-2-(benzylsulfonylamino)-3-hydroxy-pr...)
Affinity DataKi:  7nM ΔG°:  -46.4kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98590BDBM98590((2S)-3-benzyloxy-2-[[(2R)-2-(benzylsulfonylamino)-...)
Affinity DataKi:  11nM ΔG°:  -45.3kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98583BDBM98583(4-[[(1R)-2-[[(1S)-2-[(4-carbamimidoylphenyl)methyl...)
Affinity DataKi:  13nM ΔG°:  -44.9kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98593BDBM98593(methyl 4-[[(1R)-2-[[(1S)-2-[(4-carbamimidoylphenyl...)
Affinity DataKi:  20nM ΔG°:  -43.8kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98584BDBM98584(3-[[(1R)-2-[[(1S)-2-[(4-carbamimidoylphenyl)methyl...)
Affinity DataKi:  21nM ΔG°:  -43.7kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98588BDBM98588((2S)-3-amino-2-[[(2R)-2-(benzylsulfonylamino)-3-hy...)
Affinity DataKi:  21nM ΔG°:  -43.7kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 50231520BDBM50231520(CHEMBL252937 | US8476306, 6.12 | (R)-N-[(S)-1-(4-c...)
Affinity DataKi:  22nM ΔG°:  -43.6kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98603BDBM98603(3-amino-N-[4-[[(2S)-2-[[(2R)-2-(benzylsulfonylamin...)
Affinity DataKi:  25nM ΔG°:  -43.2kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98589BDBM98589((2S)-2-[[(2R)-2-(benzylsulfonylamino)-3-hydroxy-pr...)
Affinity DataKi:  30nM ΔG°:  -42.8kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98591BDBM98591(3-[[(1R)-2-[[(1S)-2-[(4-carbamimidoylphenyl)methyl...)
Affinity DataKi:  58nM ΔG°:  -41.2kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98592BDBM98592(4-[[(1R)-2-[[(1S)-2-[(4-carbamimidoylphenyl)methyl...)
Affinity DataKi:  100nM ΔG°:  -39.8kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98596BDBM98596((2R)-N-[2-[(4-carbamimidoylphenyl)methylamino]-2-o...)
Affinity DataKi:  110nM ΔG°:  -39.6kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 50110015BDBM50110015(N-(BENZYLSULFONYL)SERYL-N~1~-{4-[AMINO(IMINO)METHY...)
Affinity DataKi:  150nM ΔG°:  -38.8kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98602BDBM98602(3-amino-N-[4-[[2-[[(2R)-3-amino-2-(benzylsulfonyla...)
Affinity DataKi:  180nM ΔG°:  -38.4kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98579BDBM98579(methyl 4-[[(1R)-2-[[2-[(4-carbamimidoylphenyl)meth...)
Affinity DataKi:  180nM ΔG°:  -38.4kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98595BDBM98595((2R)-N-[2-[(4-carbamimidoylphenyl)methylamino]-2-o...)
Affinity DataKi:  210nM ΔG°:  -38.0kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98586BDBM98586((2R)-2-[[4-(aminomethyl)phenyl]methylsulfonylamino...)
Affinity DataKi:  280nM ΔG°:  -37.3kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 50110015BDBM50110015(N-(BENZYLSULFONYL)SERYL-N~1~-{4-[AMINO(IMINO)METHY...)
Affinity DataKi:  290nM ΔG°:  -37.2kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98604BDBM98604(2-[4-[[(1R)-2-[[2-[4-[(3-amino-4-methoxy-benzoyl)a...)
Affinity DataKi:  300nM ΔG°:  -37.1kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98585BDBM98585((2R)-N-[(1S)-2-[(4-carbamimidoylphenyl)methylamino...)
Affinity DataKi:  340nM ΔG°:  -36.8kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98594BDBM98594((2R)-N-[2-[(4-carbamimidoylphenyl)methylamino]-2-o...)
Affinity DataKi:  350nM ΔG°:  -36.7kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98581BDBM98581(methyl 2-[[(1R)-2-[[2-[(4-carbamimidoylphenyl)meth...)
Affinity DataKi:  400nM ΔG°:  -36.4kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98598BDBM98598((2R)-N-[2-[(4-carbamimidoylphenyl)methylamino]-2-o...)
Affinity DataKi:  410nM ΔG°:  -36.3kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98580BDBM98580(4-[[(1R)-2-[[2-[(4-carbamimidoylphenyl)methylamino...)
Affinity DataKi:  480nM ΔG°:  -35.9kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98597BDBM98597((2R)-N-[2-[(4-carbamimidoylphenyl)methylamino]-2-o...)
Affinity DataKi:  600nM ΔG°:  -35.4kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98578BDBM98578(3-[[(1R)-2-[[2-[(4-carbamimidoylphenyl)methylamino...)
Affinity DataKi:  720nM ΔG°:  -34.9kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 98582BDBM98582(2-[[(1R)-2-[[2-[(4-carbamimidoylphenyl)methylamino...)
Affinity DataKi:  2.40E+3nM ΔG°:  -32.0kJ/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
US Patent