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TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18864(3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]pr...)
Affinity DataIC50: 0.0407nMAssay Description:Inhibition of thyroid hormone receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18864(3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]pr...)
Affinity DataIC50: 0.0410nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataKd:  0.0580nMAssay Description:Human thyroid hormone receptor alpha and beta (hTR alpha1) and (hTR beta1) were produced using TNT coupled reticulocyte lysate system from Promega.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2011
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataKd:  0.0580nMAssay Description:Displacement of [125I]T3 from human TRalpha receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataKd:  0.0580nMAssay Description:Thyroid hormone competitive binding assay using TNT T7 quick-coupled transcription translation system from promega.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2011
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataKd:  0.0600nMAssay Description:Binding affinity of compound was determined against Thyroid hormone receptor alpha1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha/beta(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50477506(CHEMBL392666)
Affinity DataEC50:  0.0600nMAssay Description:Agonist activity at THR in HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha/beta(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50477507(CHEMBL248111)
Affinity DataEC50:  0.0800nMAssay Description:Agonist activity at THR in HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataKd:  0.100nMAssay Description:Binding affinity against human Thyroid hormone receptor alpha-1 (hTRalpha1) using radiolabeled T3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18865(3-{3,5-dibromo-4-[4-hydroxy-3-(propan-2-yl)phenoxy...)
Affinity DataIC50: 0.100nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18865(3-{3,5-dibromo-4-[4-hydroxy-3-(propan-2-yl)phenoxy...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of thyroid hormone receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18862(2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]ac...)
Affinity DataIC50: 0.140nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18863((2R)-2-amino-3-{4-[4-hydroxy-3-(propan-2-yl)phenox...)
Affinity DataIC50: 0.140nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18862(2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]ac...)
Affinity DataIC50: 0.141nMAssay Description:Inhibition of thyroid hormone receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18863((2R)-2-amino-3-{4-[4-hydroxy-3-(propan-2-yl)phenox...)
Affinity DataIC50: 0.141nMAssay Description:Inhibition of thyroid hormone receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataKd:  0.170nMAssay Description:Binding affinity towards thyroid hormone receptor (hTR alpha 1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha/beta(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50163895((S)-2-Amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3-iodo...)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity towards thyroid hormone receptor expressed in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataKi:  0.220nMAssay Description:Displacement of [125I]T3 from recombinant thyroid hormone receptor alpha expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataIC50: 0.240nMAssay Description:Inhibitory concentration against cloned human thyroid hormone receptor alpha 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataIC50: 0.240nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataIC50: 0.240nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataIC50: 0.240nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50178971((R)-2-Amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-di...)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of human TR-alpha-1 by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50178971((R)-2-Amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-di...)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of thyroid hormone receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataIC50: 0.240nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha/beta(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50477505(CHEMBL248515)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at THR in HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18870(3-{3,5-dichloro-4-[4-hydroxy-3-(propan-2-yl)phenox...)
Affinity DataIC50: 0.760nM EC50:  0.300nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50063689(CHEMBL3397337)
Affinity DataKi:  0.350nMAssay Description:Displacement of [125I]-L-3,5,3'-triiodothyronine from human TRalpha expressed in human Hela cell lysate measured after overnight incubation by compet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50063687(CHEMBL3397339)
Affinity DataKi:  0.380nMAssay Description:Displacement of [125I]-L-3,5,3'-triiodothyronine from human TRalpha expressed in human Hela cell lysate measured after overnight incubation by compet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18867(dibromo phenylacetic acid, 11a | 2-{3,5-dibromo-4-...)
Affinity DataIC50: 1.40nM EC50:  0.380nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18867(dibromo phenylacetic acid, 11a | 2-{3,5-dibromo-4-...)
Affinity DataIC50: 1.40nM EC50:  0.380nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataEC50:  0.410nMAssay Description:Agonist activity at human thyroid hormone receptor alpha expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18904(2-[3,5-dibromo-4-(cyclohexylmethoxy)phenyl]acetic ...)
Affinity DataIC50: 2.70E+3nM EC50:  0.420nMpH: 7.0 T: 2°CAssay Description:IIC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50115668([4-(4-Hydroxy-3-isopropyl-benzyl)-3,5-dimethyl-phe...)
Affinity DataKd:  0.440nMAssay Description:Human thyroid hormone receptor alpha and beta (hTR alpha1) and (hTR beta1) were produced using TNT coupled reticulocyte lysate system from Promega.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThyroid hormone receptor alpha/beta(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50163906([4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-bis-trifluor...)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity towards thyroid hormone receptor expressed in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at human THRalpha expressed in baculovirus infected SF9 cells after 15 mins by gel electrophoresisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50063755(CHEMBL3397341)
Affinity DataKi:  0.510nMAssay Description:Displacement of [125I]-L-3,5,3'-triiodothyronine from human TRalpha expressed in human Hela cell lysate measured after overnight incubation by compet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50036402(N-[3,5-dimethyl-4-(4'-hydroxy-3'-isopropylphenoxy)...)
Affinity DataKi:  0.510nMAssay Description:Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18887(JMC496635 Compound 9 | 3-[3,5-dibromo-4-(cyclohexy...)
Affinity DataIC50: 460nM EC50:  0.530nMpH: 7.0 T: 2°CAssay Description:IIC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18906(3-[3,5-dibromo-4-(hexyloxy)phenyl]propanoic acid |...)
Affinity DataIC50: 1.10E+3nM EC50:  0.600nMpH: 7.0 T: 2°CAssay Description:IIC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50115668([4-(4-Hydroxy-3-isopropyl-benzyl)-3,5-dimethyl-phe...)
Affinity DataKd:  0.660nMAssay Description:Binding affinity of compound was determined against Thyroid hormone receptor alpha1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50130594(3-[4-(4-Hydroxy-3-isopropyl-benzyl)-3,5-dimethyl-p...)
Affinity DataKd:  0.690nMAssay Description:Binding affinity of compound was determined against Thyroid hormone receptor alpha1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50304777(2-(4-(7-hydroxy-2,3-dihydro-1H-inden-4-yloxy)-3,5-...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to thyroid receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataEC50:  0.700nMAssay Description:Agonist activity at human THRalpha transfected in Huh7 cells co-transfected with luciferase reporter plasmid assessed as reduction in luciferase acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18902(2-[3,5-dibromo-4-(hexyloxy)phenyl]acetic acid | 3,...)
Affinity DataIC50: 5.20E+3nM EC50:  0.700nMpH: 7.0 T: 2°CAssay Description:IIC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18870(3-{3,5-dichloro-4-[4-hydroxy-3-(propan-2-yl)phenox...)
Affinity DataIC50: 0.759nMAssay Description:Inhibition of thyroid hormone receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18903(2-[3,5-dibromo-4-(2-ethylbutoxy)phenyl]acetic acid...)
Affinity DataIC50: 6.90E+3nM EC50:  0.820nMpH: 7.0 T: 2°CAssay Description:IIC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataEC50:  1.01nMAssay Description:Human epithelial kidney cells (HEK 293) were grown to 80% confluency in Dubelcco's modified Eagles 4.5 g/L glucose medium (high glucose DMEM) con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
US Patent

TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50115668([4-(4-Hydroxy-3-isopropyl-benzyl)-3,5-dimethyl-phe...)
Affinity DataKi:  1.09nMAssay Description:Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
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