Compile Data Set for Download or QSAR
Report error Found 63 of affinity data for UniProtKB/TrEMBL: P58295
LigandChemical structure of BindingDB Monomer ID 50335008BDBM50335008(5-Biphenyl-4-yl-4-(2-fluorophenyl)-N-methyl-4H-1,2...)
Affinity DataIC50: 110nMAssay Description:Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50099875BDBM50099875((E)-2-Amino-5-(2,4-difluoro-phenyl)-5-(4-isopropyl...)
Affinity DataIC50: 150nMAssay Description:In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50335010BDBM50335010(3-Biphenyl-4-yl-5-ethyl-4-(2-fluorophenyl)-1,2,4-t...)
Affinity DataIC50: 230nMAssay Description:Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50335010BDBM50335010(3-Biphenyl-4-yl-5-ethyl-4-(2-fluorophenyl)-1,2,4-t...)
Affinity DataIC50: 230nMAssay Description:Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50335010BDBM50335010(3-Biphenyl-4-yl-5-ethyl-4-(2-fluorophenyl)-1,2,4-t...)
Affinity DataIC50: 230nMAssay Description:Displacement of [3H]glycine from Wistar rat brain GlyT2 after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50335006BDBM50335006(2-(3-Biphenyl-4-yl-5-methyl-4H-1,2,4-triazole-4-yl...)
Affinity DataIC50: 260nMAssay Description:Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50335004BDBM50335004(3-Biphenyl-4-yl-4-(2-chlorophenyl)-5-methyl-4H-1,2...)
Affinity DataIC50: 280nMAssay Description:Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50099886BDBM50099886((E)-2-Amino-5-(3,4-diethyl-phenyl)-5-(2,4-difluoro...)
Affinity DataIC50: 283nMAssay Description:In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50099859BDBM50099859(Sodium; (E)-2-amino-5-(2-fluoro-phenyl)-5-(4-isopr...)
Affinity DataIC50: 290nMAssay Description:In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50099862BDBM50099862(Sodium; (E)-2-amino-5-(2,4-difluoro-phenyl)-5-(4-i...)
Affinity DataIC50: 330nMAssay Description:In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50439743BDBM50439743(CHEMBL2419425)
Affinity DataIC50: 340nMAssay Description:Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50335001BDBM50335001(3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-methyl-4H-1,2...)
Affinity DataIC50: 340nMAssay Description:Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50335001BDBM50335001(3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-methyl-4H-1,2...)
Affinity DataIC50: 340nMAssay Description:Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50099878BDBM50099878((E)-2-Amino-5-(2,4-difluoro-phenyl)-5-naphthalen-2...)
Affinity DataIC50: 365nMAssay Description:In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50360102BDBM50360102(CHEMBL1928735)
Affinity DataIC50: 380nMAssay Description:Displacement of [3H]glycine from Wistar rat brain GlyT2 after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50099882BDBM50099882(Sodium; (Z)-2-amino-5-(4-isopropyl-phenyl)-5-pheny...)
Affinity DataIC50: 400nMAssay Description:In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50099879BDBM50099879(Sodium; (E)-2-amino-5-(2,4-difluoro-phenyl)-5-(4-e...)
Affinity DataIC50: 460nMAssay Description:In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50335005BDBM50335005(3-Biphenyl-4-yl-5-methyl-4-[2-(trifluoromethyl)phe...)
Affinity DataIC50: 600nMAssay Description:Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50099866BDBM50099866(Sodium; (E)-2-amino-5-(3,4-diethyl-phenyl)-5-(2,4-...)
Affinity DataIC50: 660nMAssay Description:In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50439737BDBM50439737(CHEMBL2419431)
Affinity DataIC50: 660nMAssay Description:Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50335007BDBM50335007(2-(3-(biphenyl-4-yl)-5-methyl-4H-1,2,4-triazol-4-y...)
Affinity DataIC50: 680nMAssay Description:Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50439745BDBM50439745(CHEMBL2419423)
Affinity DataIC50: 700nMAssay Description:Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50099883BDBM50099883(Sodium; (E)-2-amino-5-(2,4-difluoro-phenyl)-5-naph...)
Affinity DataIC50: 770nMAssay Description:In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50335012BDBM50335012(3-Biphenyl-4-yl-5-methyl-4-(2-methylphenyl)-4H-1,2...)
Affinity DataIC50: 780nMAssay Description:Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50439750BDBM50439750(CHEMBL2419441)
Affinity DataIC50: 790nMAssay Description:Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50439749BDBM50439749(CHEMBL2417571)
Affinity DataIC50: 890nMAssay Description:Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50335009BDBM50335009(3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-methoxy-4H-1,...)
Affinity DataIC50: 990nMAssay Description:Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50099858BDBM50099858(Sodium; (E)-2-amino-5-(4-isopropyl-phenyl)-5-thiop...)
Affinity DataIC50: 1.03E+3nMAssay Description:In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50099873BDBM50099873(Sodium; (E)-2-amino-5-(4-isopropyl-phenyl)-5-(4-me...)
Affinity DataIC50: 1.16E+3nMAssay Description:In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50099863BDBM50099863(Sodium; (E)-2-amino-5-(2,4-difluoro-phenyl)-5-p-to...)
Affinity DataIC50: 1.17E+3nMAssay Description:In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50439744BDBM50439744(CHEMBL2419424)
Affinity DataIC50: 1.20E+3nMAssay Description:Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50439741BDBM50439741(CHEMBL2419427)
Affinity DataIC50: 1.30E+3nMAssay Description:Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50099868BDBM50099868(Sodium; (E)-2-amino-5-biphenyl-3-yl-5-(2,4-difluor...)
Affinity DataIC50: 1.34E+3nMAssay Description:In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50334998BDBM50334998(3-Biphenyl-4-yl-5-methyl-4-phenyl-4H-1,2,4-triazol...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50099861BDBM50099861(Sodium; (E)-2-amino-5-(2,4-difluoro-phenyl)-5-(3-i...)
Affinity DataIC50: 1.59E+3nMAssay Description:In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50439751BDBM50439751(CHEMBL2419444)
Affinity DataIC50: 1.60E+3nMAssay Description:Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50114035BDBM50114035(3-Biphenyl-4-yl-4-(2-methoxy-phenyl)-5-methyl-4H-[...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50099881BDBM50099881((E)-2-Amino-5-(4-tert-butyl-phenyl)-5-(2,4-difluor...)
Affinity DataIC50: 1.74E+3nMAssay Description:In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50099880BDBM50099880(Sodium; (E)-2-amino-5-(2,4-difluoro-phenyl)-5-(4-m...)
Affinity DataIC50: 2.03E+3nMAssay Description:In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50099865BDBM50099865(Sodium; 2-amino-5,5-bis-(4-isopropyl-phenyl)-pent-...)
Affinity DataIC50: 2.03E+3nMAssay Description:In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50099885BDBM50099885(Sodium; (E)-2-amino-5-biphenyl-4-yl-5-(4-isopropyl...)
Affinity DataIC50: 2.06E+3nMAssay Description:In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50099864BDBM50099864(Sodium; (Z)-2-amino-5-biphenyl-4-yl-5-(2,4-difluor...)
Affinity DataIC50: 2.40E+3nMAssay Description:In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50099872BDBM50099872(Sodium; (E)-2-amino-5-(4-cyano-phenyl)-5-(4-isopro...)
Affinity DataIC50: 2.64E+3nMAssay Description:In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50360091BDBM50360091(CHEMBL1928738)
Affinity DataIC50: 2.70E+3nMAssay Description:Displacement of [3H]glycine from Wistar rat brain GlyT2 after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50099870BDBM50099870(Sodium; (E)-2-amino-5-biphenyl-2-yl-5-(2,4-difluor...)
Affinity DataIC50: 2.75E+3nMAssay Description:In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50439740BDBM50439740(CHEMBL2419428)
Affinity DataIC50: 3.10E+3nMAssay Description:Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50335011BDBM50335011(3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-isopropyl-4H-...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50335011BDBM50335011(3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-isopropyl-4H-...)
Affinity DataIC50: 3.30E+3nMAssay Description:Displacement of [3H]glycine from Wistar rat brain GlyT2 after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50099877BDBM50099877(Sodium; (E)-2-amino-5-biphenyl-4-yl-5-(2,4-difluor...)
Affinity DataIC50: 3.66E+3nMAssay Description:In vitro glycine reuptake inhibitory activity against glycine transporter type-2 (GlyT-2) transporter cells after incubation at 30 degrees for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50360092BDBM50360092(CHEMBL1928736)
Affinity DataIC50: 4.20E+3nMAssay Description:Displacement of [3H]glycine from Wistar rat brain GlyT2 after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
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