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TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.199nMAssay Description:Inhibition of human IKKepsilon using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM276896(US10072001, Example 82 | US10259811, Example 82)
Affinity DataIC50: 0.290nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM276896(US10072001, Example 82 | US10259811, Example 82)
Affinity DataIC50: 0.290nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.439nMAssay Description:Inhibition of human IKKepsilon using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM276969(US10072001, Example 145 | US10259811, Example 145)
Affinity DataIC50: 0.481nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM276969(US10072001, Example 145 | US10259811, Example 145)
Affinity DataIC50: 0.481nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM276965(US10072001, Example 141 | US10259811, Example 141)
Affinity DataIC50: 0.687nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM276965(US10072001, Example 141 | US10259811, Example 141)
Affinity DataIC50: 0.687nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM276877(US10072001, Example 63 | US10259811, Example 63)
Affinity DataIC50: 0.710nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM276877(US10072001, Example 63 | US10259811, Example 63)
Affinity DataIC50: 0.710nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM276879(US10072001, Example 65 | US10259811, Example 65)
Affinity DataIC50: 0.770nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM276879(US10072001, Example 65 | US10259811, Example 65)
Affinity DataIC50: 0.770nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM276868(US10072001, Example 54 | US10259811, Example 54)
Affinity DataIC50: 0.810nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM276868(US10072001, Example 54 | US10259811, Example 54)
Affinity DataIC50: 0.810nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM277059(US10072001, Example 251 | US10259811, Example 251)
Affinity DataIC50: 0.815nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM277059(US10072001, Example 251 | US10259811, Example 251)
Affinity DataIC50: 0.815nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM277037(US10072001, Example 229 | US10259811, Example 229)
Affinity DataIC50: 0.851nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM277037(US10072001, Example 229 | US10259811, Example 229)
Affinity DataIC50: 0.851nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278079((S)-2-((1-acetyl-3,3-difluoropiperidin-4-yl)oxy)-5...)
Affinity DataIC50: 1nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278238(2-(((S)-3,3-difluoro-1-((S)-2-hydroxypropanoyl)pip...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278323(2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)pip...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278082((S)-2-((3,3-difluoro-1-formylpiperidin-4-yl)oxy)-5...)
Affinity DataIC50: 1nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278083(2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-...)
Affinity DataIC50: 1nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278074(2-(((3R,4S)-3-fluoro-1-formylpiperidin-4-yl)oxy)-5...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM375573(5-(4-((3-fluoro-4-(piperazin-1-yl)phenyl)amino)-1,...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278247(2-(((S)-3,3-difluoro-1-((S)-2-hydroxypropanoyl)pip...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278084(2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-...)
Affinity DataIC50: 1nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278161(2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)pip...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278080((S)-2-((1-acetyl-3,3-difluoropiperidin-4-yl)oxy)-5...)
Affinity DataIC50: 1nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278081((S)-2-((3,3-difluoro-1-formylpiperidin-4-yl)oxy)-5...)
Affinity DataIC50: 1nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278080((S)-2-((1-acetyl-3,3-difluoropiperidin-4-yl)oxy)-5...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278167(2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)pip...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278338((S)-2-((3,3-difluoro-1-(2-hydroxyacetyl)piperidin-...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278081((S)-2-((3,3-difluoro-1-formylpiperidin-4-yl)oxy)-5...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278162(2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278333(2-(((3R,4S)-1-((S)-2,3-dihydroxypropanoyl)-3-fluor...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278079((S)-2-((1-acetyl-3,3-difluoropiperidin-4-yl)oxy)-5...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278171(5-(4-((3-(difluoromethoxy)-4-(4-(oxetan-3-yl)piper...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278085(2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
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TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278256((3R,4S)-4-(2-cyano-4-(4-((4-(4-(oxetan-3-yl)pipera...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278170(2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278087(2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)pip...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278172(2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278086(2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)pip...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278257(2-(((S)-1-((S)-2,3-dihydroxypropanoyl)-3,3-difluor...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278083(2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278339(2-(((S)-3,3-difluoro-1-((S)-2-hydroxypropanoyl)pip...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278082((S)-2-((3,3-difluoro-1-formylpiperidin-4-yl)oxy)-5...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278015(2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM278007(2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-...)
Affinity DataIC50: 1nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

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