Compile Data Set for Download or QSAR
Report error Found 2654 of affinity data for UniProtKB/TrEMBL: Q15153
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50343559BDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 0.00200nMAssay Description:Inhibition of PLK1 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25121BDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50: 0.0830nMAssay Description:Inhibition of PLK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50355500BDBM50355500(CHEMBL1908394 | US9695172, GSK461364)
Affinity DataKd:  0.0940nMAssay Description:Binding constant for PLK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621090BDBM50621090(CHEMBL5417495)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by ADP-Glo kinase assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626599BDBM50626599(CHEMBL5423881)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25121BDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataKd:  0.190nMAssay Description:Binding constant for PLK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626575BDBM50626575(CHEMBL5419732)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526296BDBM50526296(CHEMBL4449858)
Affinity DataKd:  0.190nMAssay Description:Binding affinity to PLK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25121BDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataKd:  0.190nMAssay Description:Binding affinity to PLK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621081BDBM50621081(CHEMBL5416208)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by ADP-Glo kinase assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25121BDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataKi:  0.220nMAssay Description:Binding affinity to PLK1 (unknown origin) expressed in HEK293 cells after 1 hr by proprietary competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626583BDBM50626583(CHEMBL5433401)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626579BDBM50626579(CHEMBL5438707)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626606BDBM50626606(CHEMBL5415945)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621072BDBM50621072(CHEMBL5426964)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by ADP-Glo kinase assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626573BDBM50626573(CHEMBL5421113)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621077BDBM50621077(CHEMBL5419367)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by ADP-Glo kinase assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621046BDBM50621046(CHEMBL5429440)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by ADP-Glo kinase assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621080BDBM50621080(CHEMBL5422122)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by ADP-Glo kinase assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626602BDBM50626602(CHEMBL5435085)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626587BDBM50626587(CHEMBL5429110)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626593BDBM50626593(CHEMBL5438696)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626603BDBM50626603(CHEMBL5398211)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626577BDBM50626577(CHEMBL5396078)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621071BDBM50621071(CHEMBL5427957)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by ADP-Glo kinase assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626576BDBM50626576(CHEMBL5437785)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50232582BDBM50232582(CHEMBL4067710)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human FLAG-tagged PLK1 expressed in baculovirus infected sf21 cells using Biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621086BDBM50621086(CHEMBL5403473)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by ADP-Glo kinase assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626588BDBM50626588(CHEMBL5402308)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626586BDBM50626586(CHEMBL5426743)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50112336BDBM50112336(CHEMBL3609305)
Affinity DataKi:  0.420nMAssay Description:Binding affinity to PLK1 (unknown origin) expressed in HEK293 cells after 1 hr by proprietary competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621049BDBM50621049(CHEMBL5410968)
Affinity DataIC50: 0.430nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by ADP-Glo kinase assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626594BDBM50626594(CHEMBL5394854)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626601BDBM50626601(CHEMBL5430344)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626598BDBM50626598(CHEMBL5433215)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621070BDBM50621070(CHEMBL5403358)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by ADP-Glo kinase assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621076BDBM50621076(CHEMBL5395480)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by ADP-Glo kinase assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621074BDBM50621074(CHEMBL5418129)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by ADP-Glo kinase assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50355500BDBM50355500(CHEMBL1908394 | US9695172, GSK461364)
Affinity DataKi: <0.5nMAssay Description:Time-dependent inhibition of full length human PLK1 assessed as apparent dissociation constant by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626589BDBM50626589(CHEMBL5435649)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621047BDBM50621047(CHEMBL5401381)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by ADP-Glo kinase assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50565569BDBM50565569(CHEMBL4780069)
Affinity DataIC50: 0.508nMAssay Description:Inhibition of human PLK1 using casein as substrate in presence of [gamma-33P]ATP by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50565570BDBM50565570(CHEMBL4798376)
Affinity DataIC50: 0.508nMAssay Description:Inhibition of human PLK1 using casein as substrate in presence of [gamma-33P]ATP by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50565556BDBM50565556(CHEMBL4787929)
Affinity DataIC50: 0.508nMAssay Description:Inhibition of human PLK1 using casein as substrate in presence of [gamma-33P]ATP by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50565572BDBM50565572(CHEMBL4800688)
Affinity DataIC50: 0.508nMAssay Description:Inhibition of human PLK1 using casein as substrate in presence of [gamma-33P]ATP by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50565559BDBM50565559(CHEMBL4792017)
Affinity DataIC50: 0.508nMAssay Description:Inhibition of human PLK1 using casein as substrate in presence of [gamma-33P]ATP by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25121BDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621050BDBM50621050(CHEMBL5412127)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by ADP-Glo kinase assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621048BDBM50621048(CHEMBL5421238)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by ADP-Glo kinase assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50112340BDBM50112340(CHEMBL3609310)
Affinity DataKi:  0.520nMAssay Description:Binding affinity to PLK1 (unknown origin) expressed in HEK293 cells after 1 hr by proprietary competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
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