Compile Data Set for Download or QSAR
Report error Found 243 of affinity data for UniProtKB/TrEMBL: Q8N6P0
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 223288BDBM223288((1S,2S)-2-[(5-{(2-Fluoro-2-methylpropyl)[2-fluoro-...)
Affinity DataIC50: 0.248nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 223288BDBM223288((1S,2S)-2-[(5-{(2-Fluoro-2-methylpropyl)[2-fluoro-...)
Affinity DataIC50: 0.248nMpH: 7.5Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester. In order to obtain IC50-v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details
US Patent

TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 223288BDBM223288((1S,2S)-2-[(5-{(2-Fluoro-2-methylpropyl)[2-fluoro-...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519568BDBM50519568(CHEMBL4549822)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 223287BDBM223287((1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-flu...)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 223287BDBM223287((1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-flu...)
Affinity DataIC50: 0.289nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 223287BDBM223287((1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-flu...)
Affinity DataIC50: 0.289nMpH: 7.5Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester. In order to obtain IC50-v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519570BDBM50519570(CHEMBL4567083)
Affinity DataIC50: 0.360nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519585BDBM50519585(CHEMBL4464773)
Affinity DataIC50: 0.381nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 310035BDBM310035(US9657001, 64 | (1S,2S)-2-({5-[(5-Chloro-2,4-diflu...)
Affinity DataIC50: 0.483nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 223289BDBM223289((1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(propy...)
Affinity DataIC50: 0.483nMpH: 7.5Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester. In order to obtain IC50-v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details
US Patent

TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519591BDBM50519591(CHEMBL4562583)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519574BDBM50519574(CHEMBL4563433)
Affinity DataIC50: 0.626nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519588BDBM50519588(CHEMBL4584584)
Affinity DataIC50: 0.630nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 223290BDBM223290((1S,2S)-2-[(5-{[2-Fluoro-5-(trifluoromethyl)phenyl...)
Affinity DataIC50: 0.658nMpH: 7.5Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester. In order to obtain IC50-v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details
US Patent

TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 223290BDBM223290((1S,2S)-2-[(5-{[2-Fluoro-5-(trifluoromethyl)phenyl...)
Affinity DataIC50: 0.658nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 223290BDBM223290((1S,2S)-2-[(5-{[2-Fluoro-5-(trifluoromethyl)phenyl...)
Affinity DataIC50: 0.660nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519580BDBM50519580(CHEMBL4574439)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519565BDBM50519565(CHEMBL4441362)
Affinity DataIC50: 0.758nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519567BDBM50519567(CHEMBL4476024)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519571BDBM50519571(CHEMBL4454609)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519595BDBM50519595(CHEMBL4545014)
Affinity DataIC50: 2nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50623420BDBM50623420(CHEMBL5417047)
Affinity DataIC50: 2nMAssay Description:Inhibition of LTC4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519569BDBM50519569(CHEMBL4545950)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519585BDBM50519585(CHEMBL4464773)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519582BDBM50519582(CHEMBL4525972)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519570BDBM50519570(CHEMBL4567083)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519587BDBM50519587(CHEMBL4467942)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519568BDBM50519568(CHEMBL4549822)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519590BDBM50519590(CHEMBL4574370)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519592BDBM50519592(CHEMBL4442047)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50623417BDBM50623417(CHEMBL5432381)
Affinity DataIC50: 5nMAssay Description:Inhibition of LTC4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519579BDBM50519579(CHEMBL4576647)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519575BDBM50519575(CHEMBL4567339)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 223290BDBM223290((1S,2S)-2-[(5-{[2-Fluoro-5-(trifluoromethyl)phenyl...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519574BDBM50519574(CHEMBL4563433)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 223288BDBM223288((1S,2S)-2-[(5-{(2-Fluoro-2-methylpropyl)[2-fluoro-...)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519586BDBM50519586(CHEMBL4439499)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519580BDBM50519580(CHEMBL4574439)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519577BDBM50519577(CHEMBL4439148)
Affinity DataIC50: 8.70nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 223261BDBM223261(2-(5-((Cyclopropylmethyl)(1,2-dihydroacenaphthylen...)
Affinity DataIC50: 9nMpH: 7.8Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 is converted to LTC4. Recombinant human LTC4 synthase is expressed in Pic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details
US Patent

TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 223261BDBM223261(2-(5-((Cyclopropylmethyl)(1,2-dihydroacenaphthylen...)
Affinity DataIC50: 9nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519571BDBM50519571(CHEMBL4454609)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 223287BDBM223287((1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-flu...)
Affinity DataIC50: 10nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519578BDBM50519578(CHEMBL4445815)
Affinity DataIC50: 12nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519589BDBM50519589(CHEMBL4531985)
Affinity DataIC50: 13nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519569BDBM50519569(CHEMBL4545950)
Affinity DataIC50: 14nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519566BDBM50519566(CHEMBL4565208)
Affinity DataIC50: 14nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519573BDBM50519573(CHEMBL4456770)
Affinity DataIC50: 16nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50519591BDBM50519591(CHEMBL4562583)
Affinity DataIC50: 16nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
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