Compile Data Set for Download or QSAR
Report error Found 64 of affinity data for UniProtKB/TrEMBL: Q8TCC7
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM82898(SMR000386987 | MLS001048966 | (6R,7R)-3-(acetyloxy...)
Affinity DataKi:  40nMAssay Description:TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50350468(CEFAMANDOLE)
Affinity DataKi:  46nMAssay Description:TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50335523(Claforan | Kefotex | cefotaxim | cefotaxime | (6R,...)
Affinity DataKi:  290nMAssay Description:TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50370587(CEFAZOLIN)
Affinity DataKi:  550nMAssay Description:TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50537497(CHEMBL4519013)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of OAT3 (unknown origin) expressed in HEK293 cells assessed as reduction in 6-CF uptake measured after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50537500(CHEMBL4562825)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of OAT3 (unknown origin) expressed in HEK293 cells assessed as reduction in 6-CF uptake measured after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50537498(CHEMBL4584575)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of OAT3 (unknown origin) expressed in HEK293 cells assessed as reduction in 6-CF uptake measured after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50390999(CEFOPERAZONE)
Affinity DataKi:  1.89E+3nMAssay Description:TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50537496(CHEMBL4527448)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of OAT3 (unknown origin) expressed in HEK293 cells assessed as reduction in 6-CF uptake measured after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50538736(CHEMBL4640580)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibition of human OAT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50350473(Aliporina | CEFALORIDINE)
Affinity DataKi:  2.46E+3nMAssay Description:TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50537501(CHEMBL4582456)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of OAT3 (unknown origin) expressed in HEK293 cells assessed as reduction in 6-CF uptake measured after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50003019(8-(Hexahydro-2,5-methano-pentalen-3a-yl)-1,3-dipro...)
Affinity DataKi:  3.70E+3nMAssay Description:TP_TRANSPORTER: inhibition of E1S uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50049707((6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-methoxy...)
Affinity DataKi:  4.39E+3nMAssay Description:TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50206509(CHEMBL897 | 4-Dipropylsulfamoyl-benzoic acid(probe...)
Affinity DataKi:  4.41E+3nMAssay Description:TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM85245(NSC_4856 | CAS_36322-90-4 | Piroxicam)
Affinity DataKi:  4.88E+3nMAssay Description:TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50206509(CHEMBL897 | 4-Dipropylsulfamoyl-benzoic acid(probe...)
Affinity DataIC50: 4.93E+3nMAssay Description:TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in hOAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataKi:  5.95E+3nMAssay Description:TP_TRANSPORTER: inhibition of MTX uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50305842(trans-4-((5-(2-(4-fluorobenzylcarbamoyl)-6-methylp...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human OAT3 expressed in HEK cells assessed as reduction of [3H]-estrone sulfate uptake by radioactivity counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2017
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50537502(CHEMBL38650 | NSC-220968)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of OAT3 (unknown origin) expressed in HEK293 cells assessed as reduction in 6-CF uptake measured after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50133599(CHEMBL119625 | YM-872 | (7-Imidazol-1-yl-6-nitro-2...)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of human OAT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50537499(CHEMBL4525573)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of OAT3 (unknown origin) expressed in HEK293 cells assessed as reduction in 6-CF uptake measured after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50485608(CHEBI:28837 | Caprylic acid | EDENOR C 8-98-100 | ...)
Affinity DataKi:  8.60E+3nMAssay Description:TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50350467(BL-S578 | Cefadrops | CEFADROXIL)
Affinity DataKi:  8.62E+3nMAssay Description:TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50350467(BL-S578 | Cefadrops | CEFADROXIL)
Affinity DataKi:  8.62E+3nMAssay Description:Inhibition of human OAT3 using estrone-3-sulfate as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2016
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50206509(CHEMBL897 | 4-Dipropylsulfamoyl-benzoic acid(probe...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of OAT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50206509(CHEMBL897 | 4-Dipropylsulfamoyl-benzoic acid(probe...)
Affinity DataKi:  9.00E+3nMAssay Description:TP_TRANSPORTER: inhibition of E1S uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50344964(Betamipron | N-(phenylcarbonyl)-beta-alanine | CHE...)
Affinity DataIC50: 9.92E+3nMAssay Description:TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in hOAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50646058(CHEMBL4752051)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of OAT3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM20688((3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-...)
Affinity DataIC50: 1.37E+4nMAssay Description:TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in hOAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50344961(citrinin | CHEMBL510139)
Affinity DataKi:  1.54E+4nMAssay Description:TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50265079(CHEMBL496942 | 4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLP...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human OAT3 expressed in HEK cells assessed as reduction of [3H]-estrone sulfate uptake by radioactivity counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2017
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM423212(US10501449, Example 83-I)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of OAT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50240008(CHEBI:104011 | Aminohippuric Acid | PAHA | Para-Am...)
Affinity DataKi:  1.96E+4nMAssay Description:TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50180512(1-methyl-5-vinyl-9,10-dihydrophenanthrene-2,7-diol...)
Affinity DataIC50: 2.27E+4nMAssay Description:Inhibition of OAT3 (unknown origin) expressed in HEK293 cells assessed as reduction in 6-CF uptake measured after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM207624(US9260440, 69 | US9617273, Example 69 | US10501467...)
Affinity DataIC50: 2.39E+4nMAssay Description:Inhibition of OAT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50206509(CHEMBL897 | 4-Dipropylsulfamoyl-benzoic acid(probe...)
Affinity DataKi:  2.98E+4nMAssay Description:TP_TRANSPORTER: inhibition of MTX uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM311267(US10155760, Example 123 | (S)-1-((2′,6-bis(d...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of OAT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50511112(CHEMBL4567446)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human SLC22A8 expressed in HEK293 cells in presence of para-aminohippuric acid/metforminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50009999(CHEMBL461 | N-benzoylglycine)
Affinity DataKi:  3.10E+4nMAssay Description:TP_TRANSPORTER: inhibition of benzylpenicillin uptake in OAT3-expressing HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50022309(3,5-Dioxo-1,2-diphenyl-4-n-butylpyrazolidine | 4-n...)
Affinity DataKi:  3.47E+4nMAssay Description:TP_TRANSPORTER: inhibition of MTX uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50206509(CHEMBL897 | 4-Dipropylsulfamoyl-benzoic acid(probe...)
Affinity DataIC50: 4.04E+4nMAssay Description:Experimental results: The compounds had no obvious inhibitory effect on the drug transporter OAT3, and when the compounds were used clinically in com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50344964(Betamipron | N-(phenylcarbonyl)-beta-alanine | CHE...)
Affinity DataKi:  4.83E+4nMAssay Description:TP_TRANSPORTER: inhibition of E1S uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM311268(US10155760, Example 124 | (S)-1-((2′,4-bis(d...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of OAT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM22889(N-methyl-N-[2-(5-methyl-1H-4-imidazolylmethylsulfa...)
Affinity DataKi:  5.30E+4nMAssay Description:TP_TRANSPORTER: inhibition of E1S uptake in OAT3 expressing oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50234348(4-((6-(4-methoxybenzylcarbamoyl)-4-oxopyrido[3,4-d...)
Affinity DataIC50: 5.90E+4nMAssay Description:Inhibition of human OAT3 expressed in HEK cells assessed as reduction of [3H]-estrone sulfate uptake by radioactivity counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2017
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM22889(N-methyl-N-[2-(5-methyl-1H-4-imidazolylmethylsulfa...)
Affinity DataIC50: 9.24E+4nMAssay Description:TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in hOAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50022787((+)-3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-...)
Affinity DataKi:  9.76E+4nMAssay Description:TP_TRANSPORTER: inhibition of MTX uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50228403(8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of OAT3 (unknown origin) expressed in HEK293 cells assessed as reduction of [3H]E-sul substrate uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM664709(US20240116873, Compound D)
Affinity DataIC50: 1.00E+5nMAssay Description:Experimental results: The compounds had no obvious inhibitory effect on the drug transporter OAT3, and when the compounds were used clinically in com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

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