Compile Data Set for Download or QSAR
Report error Found 688 of affinity data for UniProtKB/TrEMBL: Q8TCW9
TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM463303((-)-(2R)-1-(2-Methoxybenzyl)- N-(9-chloro-3,4-dihy...)
Affinity DataKi:  1.49nMAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM463304((-)-(2R)-1-(3-Methoxybenzyl)- N-(9-chloro-3,4-dihy...)
Affinity DataKi:  2.5nMAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM463306((-)-(2R)-1-(4-Fluoro-3- methoxybenzyl)-N-(9-chloro...)
Affinity DataKi:  2.60nMAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM463307((-)-(3R)-1-(benzimidazol-4- ylmethyl)-N-(9-chloro-...)
Affinity DataKi:  2.60nMAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM463308((-)-(2R)-2-Methyl-3- (benzimidazol-4- ylmethylamin...)
Affinity DataKi:  3.5nMAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM463321((-)-(2R)-1-(4,6-Difluoro-3- methoxybenzyl)-N-(9-ch...)
Affinity DataKi:  4.09nMAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM463326((+-)-2-Methyl-3-((3-hydroxy-4- fluoro)benzylamino)...)
Affinity DataKi:  4.40nMAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM463309((+-)-2-Methyl-3-(benzimidazol- 4-ylmethylamino)-N-...)
Affinity DataKi:  5.60nMAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM463316((-)-(3R)-1-(4,6-Difluoro-3- methoxybenzyl)-N-(9-ch...)
Affinity DataKi:  6.14nMAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM463313((-)-(2R)-1-(5-fluro- benzimidazol-4-ylmethyl)-N- (...)
Affinity DataKi:  6.14nMAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM463305((-)-(2R)-1-(4-Fluoro-2- methoxybenzyl)-N-(9-chloro...)
Affinity DataKi:  7.30nMAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM463325((-)-(2R)-1-(5-Fluoro-2- methoxybenzyl)-N-(9-chloro...)
Affinity DataKi:  7.30nMAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM463312((-)-(2R)-1-(benzimidazol-4- ylmethyl)-N-(9-chloro-...)
Affinity DataKi:  8.40nMAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM463319((-)-(3R)-1-(5-Fluoro-2- methoxybenzyl)-N-(9-chloro...)
Affinity DataKi:  9.30nMAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM463315((-)-(3R)-1-(4-Fluoro-2- methoxybenzyl)-N-(9-chloro...)
Affinity DataKi:  9.32nMAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM463324((-)-(2R)-1-(6-Fluoro-3- methoxybenzyl)-N-(9-chloro...)
Affinity DataKi:  10nMAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM463323((-)-(3R)-1-(4,6-Difluoro-3- methoxybenzyl)-N-(9-ch...)
Affinity DataKi:  13.8nMAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM50294596(1-(2-(5-(4-chlorobenzyl)-1-(4-methoxybenzyl)-4,6-d...)
Affinity DataIC50: 19nMAssay Description:Antagonist activity at human PKR1 expressed in HEK293 cells assessed as inhibition of PK1-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM50294589(1-(2-(1,5-bis(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-t...)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at human PKR1 expressed in HEK293 cells assessed as inhibition of PK1-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM50294586(1-(2-(5-(3,4-dichlorobenzyl)-1-(4-methoxybenzyl)-4...)
Affinity DataIC50: 22nMAssay Description:Antagonist activity at human PKR1 expressed in HEK293 cells assessed as inhibition of PK1-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM26335(3-[2-({5-[(4-ethylphenyl)methyl]-1-[(4-methoxyphen...)
Affinity DataKi:  22nM ΔG°:  -45.5kJ/molepH: 7.4 T: 2°CAssay Description:Nonspecific binding was determined in the presence of 1 uM Bv8. Displacement curves were determined in triplicate. The inhibition constant (Ki) of th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2009
Entry Details Article
PubMed
TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM50294601(1-(2-(1-(4-hydroxybenzyl)-5-(4-methoxybenzyl)-4,6-...)
Affinity DataIC50: 27nMAssay Description:Antagonist activity at human PKR1 expressed in HEK293 cells assessed as inhibition of PK1-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM347545(4-{[3-(4-Chloro-2-methylphenyl)piperidin-1-yl]carb...)
Affinity DataIC50: 30nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM347538(4-{[3-(4-Chloro-2-methylphenyl)piperidin-1-yl]carb...)
Affinity DataIC50: 30nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM347585(5-{[3-(4-Chloro-2-methylphenyl)piperidin-1-yl]carb...)
Affinity DataIC50: 30nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM50294585(1-(2-(5-(4-fluorobenzyl)-1-(4-methoxybenzyl)-4,6-d...)
Affinity DataIC50: 33nMAssay Description:Antagonist activity at human PKR1 expressed in HEK293 cells assessed as inhibition of PK1-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM349633(2-(4-Chlorophenyl)-2-(1-((3,5-dimethyl-1H-pyrazol-...)
Affinity DataIC50: 40nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM347577(4-{[3-(4-Methoxy-2-methylphenyl)piperidin-1-yl]car...)
Affinity DataIC50: 40nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM349645(2-(4-Chlorophenyl)-2-(1-((1,3,5-trimethyl-1H-pyraz...)
Affinity DataIC50: 40nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM463320((-)-(3R)-1-(5-Fluoro-3- methoxybenzyl)-N-(9-chloro...)
Affinity DataKi:  41.5nMAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM463322((+-)-2-Methyl-3-((3-methoxy- 4,6-difluoro)benzylam...)
Affinity DataKi:  43.5nMAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM50294604(1-(2-(5-(3,4-dichlorobenzyl)-1-(4-(difluoromethoxy...)
Affinity DataIC50: 47nMAssay Description:Antagonist activity at human PKR1 expressed in HEK293 cells assessed as inhibition of PK1-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM250600(US9475795, 79 | US10167273, Example 79 | US1054412...)
Affinity DataIC50: 50nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM250600(US9475795, 79 | US10167273, Example 79 | US1054412...)
Affinity DataIC50: 50nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM250600(US9475795, 79 | US10167273, Example 79 | US1054412...)
Affinity DataIC50: 50nMAssay Description:The ability of a compound to block the intracellular release of calcium mediated by PK1 in RBL2H3 cells expressing human PKR1 receptors is determined...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM347578(4-({3-[4-Methoxy-2-(trifluoromethyl)phenyl]piperid...)
Affinity DataIC50: 50nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM347571(4-({3-[4-Chloro-2-(trifluoromethyl)phenyl]piperidi...)
Affinity DataIC50: 50nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM349636(2-(4-Chlorophenyl)-2-(1-((3,5-diethyl-1H-pyrazol-4...)
Affinity DataIC50: 50nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM250600(US9475795, 79 | US10167273, Example 79 | US1054412...)
Affinity DataIC50: 50nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM50294603(1-(2-(5-(4-methoxybenzyl)-1-((6-methoxypyridin-3-y...)
Affinity DataIC50: 51nMAssay Description:Antagonist activity at human PKR1 expressed in HEK293 cells assessed as inhibition of PK1-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM250620(US9475795, 99 | US10167273, Example 99 | US1054412...)
Affinity DataIC50: 60nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM250620(US9475795, 99 | US10167273, Example 99 | US1054412...)
Affinity DataIC50: 60nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM250620(US9475795, 99 | US10167273, Example 99 | US1054412...)
Affinity DataIC50: 60nMAssay Description:The ability of a compound to block the intracellular release of calcium mediated by PK1 in RBL2H3 cells expressing human PKR1 receptors is determined...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM349653(3-((1-(3,5-Dimethyl-1H-pyrazol-4-yl)sulfonyl)piper...)
Affinity DataIC50: 60nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM250620(US9475795, 99 | US10167273, Example 99 | US1054412...)
Affinity DataIC50: 60nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM250599(US9475795, 78 | US10167273, Example 78 | US1054412...)
Affinity DataIC50: 70nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM250599(US9475795, 78 | US10167273, Example 78 | US1054412...)
Affinity DataIC50: 70nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM347579(4-{[3-(4-Chloro-2-ethoxyphenyl)piperidin-1-yl]carb...)
Affinity DataIC50: 70nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM250599(US9475795, 78 | US10167273, Example 78 | US1054412...)
Affinity DataIC50: 70nMAssay Description:The ability of a compound to block the intracellular release of calcium mediated by PK1 in RBL2H3 cells expressing human PKR1 receptors is determined...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
University of California

US Patent
LigandPNGBDBM250599(US9475795, 78 | US10167273, Example 78 | US1054412...)
Affinity DataIC50: 70nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
US Patent

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