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TargetProgrammed cell death 1 ligand/protein 1(Human)
Institute of Materia Medica, Chinese Academy of Medical Sciences

US Patent
LigandPNGBDBM491037(US10975049, Example 4 | (S) N-(4-(2-bromo-3-phenyl...)
Affinity DataIC50: 0.000100nMAssay Description:In vitro activity evaluation: Cisbio PD-1/PD-L1 binding assay kit was applied for the detection method of in vitro enzymology level.Screening Princip...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
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TargetProgrammed cell death 1 ligand/protein 1(Human)
Institute of Materia Medica, Chinese Academy of Medical Sciences

US Patent
LigandPNGBDBM50548983(CHEMBL4795176 | US20230303494, Compound 5)
Affinity DataKd:  0.0160nMAssay Description:Example 40: In the experiment, the instrument OctectRED of Fortebio Company based on biofilm interferometry (BLI) technology was used to capture huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
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TargetProgrammed cell death 1 ligand 1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50535763(CHEMBL4473436)
Affinity DataKd:  0.0190nMAssay Description:Binding affinity to FC-tagged human PDL1 by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand 1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM687657(US20240246964, Compound 678)
Affinity DataIC50: 0.0200nMAssay Description:PD-L1 His protein was prepared and added at the final concentration of 6 nM in the White opaque 384 well plate (Corning cat #3824BC). PD-L1 small mol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
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TargetProgrammed cell death 1 ligand 1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM687714(US20240246964, Compound 735)
Affinity DataIC50: 0.0300nMAssay Description:PD-L1 His protein was prepared and added at the final concentration of 6 nM in the White opaque 384 well plate (Corning cat #3824BC). PD-L1 small mol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
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TargetProgrammed cell death 1 ligand 1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM687659(US20240246964, Compound 680)
Affinity DataIC50: 0.0300nMAssay Description:PD-L1 His protein was prepared and added at the final concentration of 6 nM in the White opaque 384 well plate (Corning cat #3824BC). PD-L1 small mol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
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TargetProgrammed cell death 1 ligand 1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM687750(US20240246964, Compound 771)
Affinity DataIC50: 0.0300nMAssay Description:PD-L1 His protein was prepared and added at the final concentration of 6 nM in the White opaque 384 well plate (Corning cat #3824BC). PD-L1 small mol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
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TargetProgrammed cell death 1 ligand/protein 1(Human)
Institute of Materia Medica, Chinese Academy of Medical Sciences

US Patent
LigandPNGBDBM575561(US11459339, Example 41 | N,N'-(2,2'-dimethyl-[1,1'...)
Affinity DataIC50: 0.0320nMAssay Description:The effect of compounds and positive compounds of the examples of the present invention on the interaction between PD-1 and PD-L1 was determined by t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
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TargetProgrammed cell death 1 ligand/protein 1(Human)
Institute of Materia Medica, Chinese Academy of Medical Sciences

US Patent
LigandPNGBDBM575599(US11459339, Example 60 | (1s,1's,3s,3's)-3,3'-((((...)
Affinity DataIC50: 0.0340nMAssay Description:The effect of compounds and positive compounds of the examples of the present invention on the interaction between PD-1 and PD-L1 was determined by t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
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TargetProgrammed cell death 1 ligand 1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM687553(US20240246964, Compound 574)
Affinity DataIC50: 0.0400nMAssay Description:PD-L1 His protein was prepared and added at the final concentration of 6 nM in the White opaque 384 well plate (Corning cat #3824BC). PD-L1 small mol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
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TargetProgrammed cell death 1 ligand/protein 1(Human)
Institute of Materia Medica, Chinese Academy of Medical Sciences

US Patent
LigandPNGBDBM575553(US11459339, Example 37 | N,N'-(2,2'-dimethyl-[1,1'...)
Affinity DataIC50: 0.0400nMAssay Description:The effect of compounds and positive compounds of the examples of the present invention on the interaction between PD-1 and PD-L1 was determined by t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
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TargetProgrammed cell death 1 ligand/protein 1(Human)
Institute of Materia Medica, Chinese Academy of Medical Sciences

US Patent
LigandPNGBDBM50587714(CHEMBL5182195)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PD-1/PD-L1 interaction (unknown origin) by HTRF binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetProgrammed cell death 1 ligand 1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM686974(US20240246964, Compound 2)
Affinity DataIC50: 0.0400nMAssay Description:PD-L1 His protein was prepared and added at the final concentration of 6 nM in the White opaque 384 well plate (Corning cat #3824BC). PD-L1 small mol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
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TargetProgrammed cell death 1 ligand 1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM687004(US20240246964, Compound 5)
Affinity DataIC50: 0.0400nMAssay Description:PD-L1 His protein was prepared and added at the final concentration of 6 nM in the White opaque 384 well plate (Corning cat #3824BC). PD-L1 small mol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
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TargetProgrammed cell death 1 ligand 1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM687656(US20240246964, Compound 677)
Affinity DataIC50: 0.0400nMAssay Description:PD-L1 His protein was prepared and added at the final concentration of 6 nM in the White opaque 384 well plate (Corning cat #3824BC). PD-L1 small mol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
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TargetProgrammed cell death 1 ligand 1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM687047(US20240246964, Compound 48)
Affinity DataIC50: 0.0400nMAssay Description:PD-L1 His protein was prepared and added at the final concentration of 6 nM in the White opaque 384 well plate (Corning cat #3824BC). PD-L1 small mol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
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TargetProgrammed cell death 1 ligand 1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM687368(US20240246964, Compound 389)
Affinity DataIC50: 0.0460nMAssay Description:PD-L1 His protein was prepared and added at the final concentration of 6 nM in the White opaque 384 well plate (Corning cat #3824BC). PD-L1 small mol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
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TargetProgrammed cell death 1 ligand 1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM687627(US20240246964, Compound 648)
Affinity DataIC50: 0.0500nMAssay Description:PD-L1 His protein was prepared and added at the final concentration of 6 nM in the White opaque 384 well plate (Corning cat #3824BC). PD-L1 small mol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
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TargetProgrammed cell death 1 ligand/protein 1(Human)
Institute of Materia Medica, Chinese Academy of Medical Sciences

US Patent
LigandPNGBDBM50567288(CHEMBL4865838)
Affinity DataIC50: 0.0510nMAssay Description:Inhibition of PD1/PD-L1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Institute of Materia Medica, Chinese Academy of Medical Sciences

US Patent
LigandPNGBDBM50567287(CHEMBL4862360)
Affinity DataIC50: 0.0580nMAssay Description:Inhibition of PD1/PD-L1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM452150(US10710986, Example 289 | US11555029, No. 289)
Affinity DataIC50: 0.0600nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
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LigandPNGBDBM452147(US10710986, Example 286 | US11555029, No. 286)
Affinity DataIC50: 0.0600nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
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LigandPNGBDBM452113(US10710986, Example 252 | US11555029, No. 252)
Affinity DataIC50: 0.0600nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
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LigandPNGBDBM451887(US10710986, Example 26 | US11555029, No. 26)
Affinity DataIC50: 0.0600nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
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LigandPNGBDBM452008(US10710986, Example 148 | US11555029, No. 148)
Affinity DataIC50: 0.0600nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
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LigandPNGBDBM452007(US10710986, Example 147 | US11555029, No. 147)
Affinity DataIC50: 0.0600nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
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LigandPNGBDBM461503(US10774071, Example A-79)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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LigandPNGBDBM461504(US10774071, Example A-80)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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LigandPNGBDBM461501(US10774071, Example A-77)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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LigandPNGBDBM461502(US10774071, Example A-78)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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LigandPNGBDBM461499(US10774071, Example A-75)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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LigandPNGBDBM461500(US10774071, Example A-76)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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LigandPNGBDBM461497(US10774071, Example A-73)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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LigandPNGBDBM461498(US10774071, Example A-74)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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LigandPNGBDBM461495(US10774071, Example A-71)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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LigandPNGBDBM461496(US10774071, Example A-72)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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LigandPNGBDBM461493(US10774071, Example A-69)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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LigandPNGBDBM461494(US10774071, Example A-70)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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LigandPNGBDBM461491(US10774071, Example A-67)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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LigandPNGBDBM461492(US10774071, Example A-68)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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LigandPNGBDBM461489(US10774071, Example A-65)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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LigandPNGBDBM461490(US10774071, Example A-66)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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LigandPNGBDBM461519(US10774071, Example A-95)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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LigandPNGBDBM461520(US10774071, Example A-96)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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LigandPNGBDBM461517(US10774071, Example A-93)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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LigandPNGBDBM461518(US10774071, Example A-94)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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LigandPNGBDBM461515(US10774071, Example A-91)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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LigandPNGBDBM461516(US10774071, Example A-92)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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LigandPNGBDBM461514(US10774071, Example A-90)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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LigandPNGBDBM461511(US10774071, Example A-87)
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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