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Report error Found 18 for UniProtKB: Q9UBL3
TargetSet1/Ash2 histone methyltransferase complex subunit ASH2(Human)
Memorial Sloan-Kettering Cancer Center

US Patent
LigandPNGBDBM685914(US12043645, Example 7)
Affinity DataIC50: 20nMAssay Description:This assay relies on Whatman P-81 filter paper, which binds peptides but not SAM. Protein Methyl Transferases (PMTs) transfer 3H-Me of [3H-Me]-SAM to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
US Patent

TargetSet1/Ash2 histone methyltransferase complex subunit ASH2(Human)
Memorial Sloan-Kettering Cancer Center

US Patent
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  60nMAssay Description:Binding affinity against ASH2L (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSet1/Ash2 histone methyltransferase complex subunit ASH2(Human)
Memorial Sloan-Kettering Cancer Center

US Patent
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 70nMAssay Description:Inhibition of ASH2L (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50208354(CHEMBL3884329)
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50164787(CHEMBL3798088)
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant SUMO-fused MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) expressed in Escherichia coli ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50208353(CHEMBL3884726)
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50164787(CHEMBL3798088)
Affinity DataIC50: 300nMAssay Description:Inhibition of His-SUMO-fused MLL1 (3762 to 3969 residues) interaction with His-SUMO-fused ASH2L/RBBP5/WDR5 (23 to 334 residues) (unknown origin) expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2018
Entry Details Article
PubMed
TargetSet1/Ash2 histone methyltransferase complex subunit ASH2(Human)
Memorial Sloan-Kettering Cancer Center

US Patent
LigandPNGBDBM685904(US12043645, Example 1)
Affinity DataIC50: 390nMAssay Description:This assay relies on Whatman P-81 filter paper, which binds peptides but not SAM. Protein Methyl Transferases (PMTs) transfer 3H-Me of [3H-Me]-SAM to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
US Patent

LigandPNGBDBM200723(US9233086, 10L)
Affinity DataIC50: 400nMAssay Description:Inhibition of His-SUMO-fused MLL1 (3762 to 3969 residues) interaction with His-SUMO-fused ASH2L/RBBP5/WDR5 (23 to 334 residues) (unknown origin) expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2018
Entry Details Article
PubMed
LigandPNGBDBM200723(US9233086, 10L)
Affinity DataIC50: 400nMAssay Description:Inhibition of recombinant SUMO-fused MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) expressed in Escherichia coli ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
LigandPNGBDBM200723(US9233086, 10L)
Affinity DataIC50: 750nMAssay Description:Inhibition of recombinant MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
LigandPNGBDBM200723(US9233086, 10L)
Affinity DataIC50: 900nMAssay Description:Inhibition of recombinant MLL1 (unknown origin) interaction with recombinant ASH2L/RBBP5/WDR5 (unknown origin) assessed as decrease in histone methyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2018
Entry Details Article
PubMed
LigandPNGBDBM50208372(CHEMBL3885241)
Affinity DataIC50: 1.65E+3nMAssay Description:Inhibition of recombinant MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
TargetSet1/Ash2 histone methyltransferase complex subunit ASH2(Human)
Memorial Sloan-Kettering Cancer Center

US Patent
LigandPNGBDBM685913(US12043645, Example 5)
Affinity DataIC50: 2.20E+3nMAssay Description:This assay relies on Whatman P-81 filter paper, which binds peptides but not SAM. Protein Methyl Transferases (PMTs) transfer 3H-Me of [3H-Me]-SAM to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
US Patent

LigandPNGBDBM50195362(CHEMBL3907289)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of recombinant MLL1 (unknown origin) interaction with recombinant ASH2L/RBBP5/WDR5 (unknown origin) assessed as decrease in histone methyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2018
Entry Details Article
PubMed
LigandPNGBDBM50195432(CHEMBL3957478)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of recombinant MLL1 (unknown origin) interaction with recombinant ASH2L/RBBP5/WDR5 (unknown origin) assessed as decrease in histone methyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2018
Entry Details Article
PubMed
TargetSet1/Ash2 histone methyltransferase complex subunit ASH2(Human)
Memorial Sloan-Kettering Cancer Center

US Patent
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  1.08E+4nMAssay Description:Binding affinity to human ASH2L incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataIC50: 1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2017
Entry Details Article
PubMed