Compile Data Set for Download or QSAR
Report error Found 166 for UniProtKB: Q9UBM7
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50407454(CHEMBL5281526)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of DHCR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM20607((2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethy...)
Affinity DataKd:  1nMAssay Description:Binding affinity towards antiestrogen binding site AEBSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM707172(7-[2-[(5-Chloro-6-cyclohexyl-3- pyridyl)oxy]ethyl]...)
Affinity DataKi:  1.96nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50396754(CHEMBL2172347)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of 7-dehydroxycholesterol reductase-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM707127(7-((1-(4- (Trifluoromethyl)phenoxy) cyclobutyl)met...)
Affinity DataKi:  3.70nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707051(6-(2,2-Dimethyl-3-(4- (trifluoromethyl)phenyl)prop...)
Affinity DataKi:  4.02nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707064(7-(2-Methyl-2-(4- (trifluoromethyl)phenoxy)propyl)...)
Affinity DataKi:  5.04nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707025((R)-6-(3-(4-cyclobutylphenyl)-2- methylpropyl)-2-t...)
Affinity DataKi:  5.14nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
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Date in BDB:
4/16/2025
Entry Details
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Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  5.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM707180(7-(2-((6-((trans)-4- (Trifluoromethyl)cyclohexyl) ...)
Affinity DataKi:  5.72nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707031((S)-6-(2-Methyl-3-(4- (trifluoromethyl)phenyl)prop...)
Affinity DataKi:  5.85nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707119(7-(2-(4- (Trifluoromethoxy)phenoxy)ethyl)- 2-thia-...)
Affinity DataKi:  6.54nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707024((R)-6-(3-(4-cyclobutylphenyl)-2- methylpropyl)-2-t...)
Affinity DataKi:  6.54nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707080(7-(2,2-Dimethyl-3-(4- (trifluoromethyl)phenyl)prop...)
Affinity DataKi:  7.23nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707040((S)-6-(2-Methyl-3-(4- (trifluoromethoxy)phenyl)pro...)
Affinity DataKi:  7.27nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707152(7-(2-(4-Chloro-3- fluorophenoxy)-2- methylpropyl)-...)
Affinity DataKi:  7.31nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707134(7-(2-(3-Fluoro-4- (trifluoromethyl)phenoxy)ethyl)-...)
Affinity DataKi:  7.95nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707018(6-3-(4-(2,2- Dimethylcyclopropyl)phenyl)-2- methyl...)
Affinity DataKi:  8.31nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707020(7-2-Methyl-3-(4-(tert- pentyl)phenyl)propyl)-2-thi...)
Affinity DataKi:  8.38nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707026(7-(2-Methyl-3-(4-(tert- pentyl)phenyl)propyl)-2-th...)
Affinity DataKi:  8.44nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707027(6-(2-Methyl-3-(4-(1- methylcyclopropyl)phenyl)prop...)
Affinity DataKi:  8.57nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707181(7-(2-((6-((cis)-4- (trifluoromethyl)cyclohexyl) py...)
Affinity DataKi:  8.97nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707065(6-(3-(3-Chloro-4-(4,4- difluorocyclohexyl)phenyl)-...)
Affinity DataKi:  9.23nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707130(7-(2-(4- (Trifluoromethyl)phenoxy)ethyl)- 2-thia-7...)
Affinity DataKi:  9.29nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707035(6-((S)-3-(3-Chloro-4-((1s,4R)-4- hydroxy-4- (trifl...)
Affinity DataKi:  9.31nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707036((S)-6-(3-(3-Chloro-4-(4,4- difluorocyclohexyl)phen...)
Affinity DataKi:  9.43nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707029(6-(3-(4- (Trifluoromethyl)phenyl)propyl)- 2-thia-6...)
Affinity DataKi:  9.45nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707022(6-(3-(4-Cyclopropylphenyl)-2- methylpropyl)-2-thia...)
Affinity DataKi:  9.72nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707133((R)-7-(2-(4- (trifluoromethyl)phenoxy)propyl)- 2-t...)
Affinity DataKi:  9.80nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707037((S)-6-(3-(3-Chloro-4-(4,4- difluorocyclohexyl)phen...)
Affinity DataKi:  9.86nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707116((S)-7-(2-Methyl-3-(4- (trifluoromethyl)phenyl)prop...)
Affinity DataKi:  9.98nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707093(7-(2-(3,4- Difluorophenoxy)ethyl)-2-thia- 7-azaspi...)
Affinity DataKi:  10nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707111((R)-7-(3-(3,4-difluorophenyl)-2- methylpropyl)-2-t...)
Affinity DataKi:  10.1nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707021(6-(2-Methyl-3-(4-(tert- pentyl)phenyl)propyl)-2-th...)
Affinity DataKi:  10.3nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707041((S)-6-(2-Methyl-3-(4- (trifluoromethoxy)phenyl)pro...)
Affinity DataKi:  10.5nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707034(6-((S)-3-(3-Chloro-4-((1s,4R)-4- hydroxy-4- (trifl...)
Affinity DataKi:  10.5nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707126((R)-7-(2-(3,4- difluorophenoxy)propyl)-2-thia- 7-a...)
Affinity DataKi:  10.6nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707176(7-(2-((6-Cyclohexyl-5- (trifluoromethyl)pyridin-3-...)
Affinity DataKi:  10.7nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707048(6-((R)-3-(3-Chloro-4-((1r,4R)-4- hydroxy-4- methyl...)
Affinity DataKi:  11nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707057(6-(2-(4-Cyclobutylphenoxy)-2- methylpropyl)-2-thia...)
Affinity DataKi:  11.8nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707123(7-(2-(4-Fluoro-3- (trifluoromethyl)phenoxy)-2- met...)
Affinity DataKi:  11.9nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707047(6-((R)-3-(3-Chloro-4-((1r,4R)-4- hydroxy-4- methyl...)
Affinity DataKi:  11.9nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707112(7-(3-(4- (Trifluoromethoxy)phenyl)propyl)- 2-thia-...)
Affinity DataKi:  12nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM20607((2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethy...)
Affinity DataIC50: 12nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site (AEBS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM707179(7-(2-((5-Chloro-6-((trans)-4- (trifluoromethyl)cyc...)
Affinity DataKi:  12.2nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707023(6-(3-(4-cyclobutylphenyl)-2- methylpropyl)-2-thia-...)
Affinity DataKi:  12.5nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707070(6-(2-Methoxy-3-(4- (trifluoromethyl)phenyl)propyl)...)
Affinity DataKi:  12.6nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707154(US20240400579, Example 232B)
Affinity DataKi:  12.7nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707106(7-(2-(3-Fluoro-4- (trifluoromethyl)phenoxy)-2- met...)
Affinity DataKi:  12.8nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM707019(6-(4-(4-(tert- Pentyl)phenyl)butan-2-yl)-2- thia-6...)
Affinity DataKi:  12.9nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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