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TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315769BDBM50315769(GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...)
Affinity DataEC50:  0.00800nMAssay Description:Inhibition of Aurora A in human COLO 205 cells using pHH-S10 as substrate incubated for 2 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116986BDBM116986(US8637532, 713)
Affinity DataIC50: 0.0100nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460772BDBM50460772(CHEMBL4225923)
Affinity DataKd:  0.0100nMAssay Description:Binding affinity to Aurora A (unknown origin) after 45 mins by fluorescence-based thermal stability shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460773BDBM50460773(CHEMBL4227082)
Affinity DataKd:  0.0100nMAssay Description:Binding affinity to Aurora A (unknown origin) after 45 mins by fluorescence-based thermal stability shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50516349BDBM50516349(CHEMBL4443279)
Affinity DataIC50: 0.0120nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50516346BDBM50516346(CHEMBL4476212)
Affinity DataIC50: 0.0120nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50516344BDBM50516344(CHEMBL4462759)
Affinity DataIC50: 0.0120nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315769BDBM50315769(GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...)
Affinity DataEC50:  0.0120nMAssay Description:Inhibition of Aurora A in human MX1 cells using pHH-S10 as substrate incubated for 2 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 109209BDBM109209(VX-689)
Affinity DataKi:  0.0155nM ΔG°:  -62.7kJ/mole IC50: 3.88nMT: 2°CAssay Description:Threefold dilution series of inhibitors in assay buffer were prepared in wells of a microtiter plate (final concentration stating from 2uM), and TAMR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2014
Entry Details Article
PubMed
TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315769BDBM50315769(GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...)
Affinity DataEC50:  0.0200nMAssay Description:Inhibition of Aurora A in human HCT-116 cells using pHH-S10 as substrate incubated for 2 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116550BDBM116550(US8637532, 241)
Affinity DataIC50: 0.0300nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116576BDBM116576(US8637532, 268)
Affinity DataIC50: 0.0300nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116811BDBM116811(US8637532, 537)
Affinity DataIC50: 0.0400nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50277545BDBM50277545(Alisertib | MLN8237 | CHEMBL483158 | 4-(9-chloro-7...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315769BDBM50315769(GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...)
Affinity DataEC50:  0.0460nMAssay Description:Inhibition of Aurora A in human A549 cells using pHH-S10 as substrate incubated for 2 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175305BDBM50175305(CHEMBL3600873)
Affinity DataIC50: 0.0460nMAssay Description:Inhibition of human recombinant His-tagged Aurora A expressed in Escherichia coli using RRR(GLRRASLG)4R-NH2 as substrate after 40 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116622BDBM116622(US8637532, 319)
Affinity DataIC50: 0.0500nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116749BDBM116749(US8637532, 462)
Affinity DataIC50: 0.0500nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116925BDBM116925(US8637532, 652)
Affinity DataIC50: 0.0600nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116931BDBM116931(US8637532, 658)
Affinity DataIC50: 0.0600nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116690BDBM116690(US8637532, 394)
Affinity DataIC50: 0.0600nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50503744BDBM50503744(CHEMBL4563026)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of Aurora A (unknown origin) using kemptide acetate salt as substrate after 30 mins by kinase-Glo luminescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175305BDBM50175305(CHEMBL3600873)
Affinity DataIC50: 0.0640nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175305BDBM50175305(CHEMBL3600873)
Affinity DataIC50: 0.0640nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175305BDBM50175305(CHEMBL3600873)
Affinity DataIC50: 0.0640nMAssay Description:Inhibition of recombinant His-tagged human Aurora A kinase expressed in Escherichia coli using Tetra-Kemptide and [gamma-33P]-ATP by liquid scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116623BDBM116623(US8637532, 320)
Affinity DataIC50: 0.0700nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116548BDBM116548(US8637532, 239)
Affinity DataIC50: 0.0700nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116987BDBM116987(US8637532, 714)
Affinity DataIC50: 0.0800nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116938BDBM116938(US8637532, 665)
Affinity DataIC50: 0.0800nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116954BDBM116954(US8637532, 681)
Affinity DataIC50: 0.0800nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116944BDBM116944(US8637532, 671)
Affinity DataIC50: 0.0800nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116652BDBM116652(US8637532, 352)
Affinity DataIC50: 0.0800nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116579BDBM116579(US8637532, 271)
Affinity DataIC50: 0.0800nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116639BDBM116639(US8637532, 338)
Affinity DataIC50: 0.0900nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116555BDBM116555(US8637532, 246)
Affinity DataIC50: 0.0900nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116747BDBM116747(US8637532, 459)
Affinity DataIC50: 0.0900nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116812BDBM116812(US8637532, 538)
Affinity DataIC50: 0.100nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116922BDBM116922(US8637532, 649)
Affinity DataIC50: 0.100nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 12407BDBM12407(CHEMBL205877 | 3-chloro-N-[5-({6-methoxy-7-[3-(mor...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116598BDBM116598(US8637532, 292)
Affinity DataIC50: 0.100nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 12407BDBM12407(CHEMBL205877 | 3-chloro-N-[5-({6-methoxy-7-[3-(mor...)
Affinity DataIC50: 0.100nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells, was incubated at room temperature with substrate, and test compounds in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2006
Entry Details Article
PubMed
TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116988BDBM116988(US8637532, 715)
Affinity DataIC50: 0.110nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116390BDBM116390(US8637532, 71)
Affinity DataIC50: 0.110nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116571BDBM116571(US8637532, 263)
Affinity DataIC50: 0.110nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116932BDBM116932(US8637532, 659)
Affinity DataIC50: 0.110nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50503745BDBM50503745(CHEMBL4460717)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of Aurora A (unknown origin) using kemptide acetate salt as substrate after 30 mins by kinase-Glo luminescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315769BDBM50315769(GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...)
Affinity DataEC50:  0.118nMAssay Description:Inhibition of Aurora A in human HeLa cells using pHH-S10 as substrate incubated for 2 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116758BDBM116758(US8637532, 472)
Affinity DataIC50: 0.120nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116926BDBM116926(US8637532, 653)
Affinity DataIC50: 0.120nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetAurora kinase A(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116989BDBM116989(US8637532, 716)
Affinity DataIC50: 0.120nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

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