Compile Data Set for Download or QSAR
Report error Found 102 of affinity data for UniProtKB/TrEMBL: O15393
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660961BDBM50660961(CHEMBL6174967)
Affinity DataKi:  0.0300nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660958BDBM50660958(CHEMBL6144144)
Affinity DataKi:  0.0950nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660949BDBM50660949(CHEMBL6172535)
Affinity DataKi:  0.110nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 525152BDBM525152(US10988505, Example 2 | N-0385 | Ms-QFR-kbt)
Affinity DataKi:  0.172nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660960BDBM50660960(CHEMBL6163067)
Affinity DataKi:  0.240nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660961BDBM50660961(CHEMBL6174967)
Affinity DataIC50: 0.350nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50063698BDBM50063698(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human TMPRSS2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660948BDBM50660948(CHEMBL6163291)
Affinity DataKi:  0.530nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660961BDBM50660961(CHEMBL6174967)
Affinity DataIC50: 0.590nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660949BDBM50660949(CHEMBL6172535)
Affinity DataIC50: 0.590nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660956BDBM50660956(CHEMBL6150218)
Affinity DataIC50: 0.620nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660952BDBM50660952(CHEMBL6164098)
Affinity DataIC50: 0.660nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660953BDBM50660953(CHEMBL6176630)
Affinity DataIC50: 0.660nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 525152BDBM525152(US10988505, Example 2 | N-0385 | Ms-QFR-kbt)
Affinity DataIC50: 0.670nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660955BDBM50660955(CHEMBL6167030)
Affinity DataIC50: 0.740nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660960BDBM50660960(CHEMBL6163067)
Affinity DataIC50: 0.870nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660951BDBM50660951(CHEMBL6172466)
Affinity DataIC50: 0.870nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660958BDBM50660958(CHEMBL6144144)
Affinity DataIC50: 0.890nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50606675BDBM50606675(CHEMBL3219079)
Affinity DataKi:  0.900nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50639179BDBM50639179(CHEMBL5560415)
Affinity DataIC50: 0.980nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant TMPRSS2 (106 to 492 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660963BDBM50660963(CHEMBL6159875)
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50606676BDBM50606676(CHEMBL3219087)
Affinity DataKi:  1nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50063698BDBM50063698(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Affinity DataIC50: 1nMAssay Description:Inhibition of TMPRSS2 (unknown origin) using Boc-Gln-Ala-Arg-AMC as peptide substrate pre-incubated with compound for 30 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50639184BDBM50639184(CHEMBL5557551)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant TMPRSS2 (106 to 492 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50639175BDBM50639175(CHEMBL5558547)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant TMPRSS2 (106 to 492 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660957BDBM50660957(CHEMBL6165833)
Affinity DataIC50: 1.30nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660959BDBM50660959(CHEMBL6160234)
Affinity DataIC50: 1.40nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 525151BDBM525151(US10988505, Example 1)
Affinity DataIC50: 1.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660950BDBM50660950(CHEMBL6142154)
Affinity DataIC50: 1.40nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660954BDBM50660954(CHEMBL6132920)
Affinity DataIC50: 1.40nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50649147BDBM50649147(CHEMBL5620212)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human TMPRSS2 using fluorogenic substrate preincubated with enzyme in dark for 45 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 525152BDBM525152(US10988505, Example 2 | N-0385 | Ms-QFR-kbt)
Affinity DataIC50: 1.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 525152BDBM525152(US10988505, Example 2 | N-0385 | Ms-QFR-kbt)
Affinity DataIC50: 1.90nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660948BDBM50660948(CHEMBL6163291)
Affinity DataIC50: 2.40nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50639173BDBM50639173(CHEMBL5555448)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant TMPRSS2 (106 to 492 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50236918BDBM50236918(CHEMBL4081543)
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50606671BDBM50606671(CHEMBL3219102)
Affinity DataKi:  3nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50606673BDBM50606673(CHEMBL3219100)
Affinity DataKi:  3nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50606672BDBM50606672(CHEMBL3219101)
Affinity DataKi:  3nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50606674BDBM50606674(CHEMBL3219103)
Affinity DataKi:  3nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50032698BDBM50032698(CHEMBL3354676 | N-0130)
Affinity DataIC50: 3.10nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660962BDBM50660962(CHEMBL6164215)
Affinity DataIC50: 3.20nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50639180BDBM50639180(CHEMBL5559738)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant TMPRSS2 (106 to 492 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50424712BDBM50424712(Camostat Mesilate | Foipan | CAMOSTAT)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human TMPRSS2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 525153BDBM525153(US10988505, Example 3 | N-0386 | Ac-QFR-kbt)
Affinity DataIC50: 3.90nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50649148BDBM50649148(CHEMBL5619680)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human TMPRSS2 using fluorogenic substrate preincubated with enzyme in dark for 45 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50639182BDBM50639182(CHEMBL5559988)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant TMPRSS2 (106 to 492 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 525256BDBM525256(N-0438 | (H)Arg-Glu-Phe-Arg-kbt)
Affinity DataIC50: 5.20nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50639176BDBM50639176(CHEMBL5560759)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant TMPRSS2 (106 to 492 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTransmembrane protease serine 2(Human)
University of Sherbrooke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 736194BDBM736194((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataEC50:  10nMAssay Description:Four thousand HeLa-ACE2 or Vero-TMPRSS2 cells (BPS Bioscience) were seeded into 96-well plates in DMEM (10% FBS) and incubated for 24 hours at 37°C, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

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